复杂脑网络对强迫症神经质和外向性的中介作用

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-28 DOI:10.1016/j.jad.2025.119795

Binxin Huang , Jiayue Cheng , Jian Gao , Yang Wang , Chaoyi Wu , Hanyang Ruan , Puyu Li , Huiqin Han , Zhen Wang

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引用次数: 0

摘要

人格特征显著影响强迫症（OCD），但其潜在的神经机制仍不清楚。本研究旨在确定复杂的大脑网络，调解人格特质和强迫症之间的联系，为个性化干预提供新的见解。方法对211例强迫症患者进行临床评估和rs-EEG记录。人格特征采用修订neo -五因素量表进行测量，强迫症严重程度由临床医生采用耶鲁-布朗强迫症量表进行评估。利用最小生成树对复杂脑网络进行了分析。机器学习和中介分析证实了人格特征、复杂大脑网络和强迫症之间的关系。结果神经质与强迫症呈正相关，外向性与强迫症呈负相关。δ和θ波段复杂的脑网络（直径、平均偏心率、叶分数、kappa）与强迫症显著相关。θ直径部分介导了神经质和外向性与强迫症之间的关系，而θ均值偏心率部分介导了外向性和强迫症之间的关系。结论不同的θ波直径可作为神经介质，将神经质和外向性与强迫症联系起来。这些结果表明，以theta波段为中心的神经调节是一种针对个人性格特征的潜在治疗策略。

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Complex brain networks mediation of neuroticism and extraversion on obsessive-compulsive disorder

Background

Personality traits significantly influence obsessive-compulsive disorder (OCD), yet their underlying neural mechanisms remain poorly defined. This study aimed to identify complex brain networks that mediate the association between personality traits and OCD, offering novel insights for personalized interventions.

Methods

We recruited 211 OCD patients who underwent clinical evaluations and rs-EEG recordings. Personality traits were measured using the Revised NEO-Five Factor Inventory, and OCD severity was assessed with the Yale-Brown Obsessive-Compulsive Scale by clinicians. Complex brain networks were analyzed using minimum spanning tree. Machine learning and mediation analyses validated relationships between personality traits, complex brain networks, and OCD.

Results

Neuroticism positively correlated, and extraversion negatively correlated with OCD. Delta and theta bands complex brain networks (diameter, mean eccentricity, leaf fraction, kappa) significantly associated with OCD. Theta diameter partially mediated associations between both neuroticism and extraversion with OCD, whereas theta mean eccentricity partially mediated the relationship specifically between extraversion and OCD.

Conclusions

Our findings highlight distinct theta diameter as neural mediators linking neuroticism and extraversion to OCD. These results suggest theta band focused neuromodulation as a potential therapeutic strategy tailored to individual personality profiles.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.