Caroline Li-Maloney , Gregory W. McGarr , Kelli E. King , Naoto Fujii , Tatsuro Amano , Glen P. Kenny
{"title":"探索性评估局部皮肤血管舒张剂对局部加热的反应在年轻和老年女性","authors":"Caroline Li-Maloney , Gregory W. McGarr , Kelli E. King , Naoto Fujii , Tatsuro Amano , Glen P. Kenny","doi":"10.1016/j.jtherbio.2025.104190","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To explore regional differences and potential age effects in cutaneous vascular conductance (%CVC<sub>max</sub>) during local heating in young and older females.</div></div><div><h3>Methods</h3><div>In 10 young (21.4 ± 3.4 years) and 10 older (69.8 ± 2.7 years) females, %CVC<sub>max</sub> was assessed using laser-Doppler flowmetry at the chest, abdomen, forearm, and thigh during rapid, local skin heating. Local temperature was set at 34 °C during baseline and increased to 39 °C, then 42 °C in 30 min increments each. Differences in %CVC<sub>max</sub> between and within age groups were evaluated at baseline, the initial vasodilator peak, and both the 39 °C and 42 °C heating plateaus.</div></div><div><h3>Results</h3><div>In young females, responses were similar across regions with the exception that %CVC<sub>max</sub> was reduced for the abdomen across heating phases relative to other regions (all <em>P</em> < 0.040). In contrast, calf responses in older females were greater compared to other regions during the 39 °C plateau only (all <em>P</em> < 0.049). %CVC<sub>max</sub> was greater at the abdomen during the 42 °C plateau (<em>P</em> = 0.022) for older females compared to young. Similarly, responses pooled across sites were significantly different (<em>P</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>In our exploratory study we observed regional differences for both young and older females, and the pattern of response and the heating phases where differences occurred varied. Further, no age-related differences in %CVC<sub>max</sub> were observed apart from a marginally greater response for older females at peak heating of 42 °C. These findings highlight the need to disentangle the effects of sex and age in evaluating the vascular responses to heat and provide a critical foundation for sex-specific investigations into microvascular dysfunction.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"131 ","pages":"Article 104190"},"PeriodicalIF":2.9000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An exploratory assessment of regional cutaneous vasodilator responses to local heating in young and older females\",\"authors\":\"Caroline Li-Maloney , Gregory W. McGarr , Kelli E. King , Naoto Fujii , Tatsuro Amano , Glen P. Kenny\",\"doi\":\"10.1016/j.jtherbio.2025.104190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To explore regional differences and potential age effects in cutaneous vascular conductance (%CVC<sub>max</sub>) during local heating in young and older females.</div></div><div><h3>Methods</h3><div>In 10 young (21.4 ± 3.4 years) and 10 older (69.8 ± 2.7 years) females, %CVC<sub>max</sub> was assessed using laser-Doppler flowmetry at the chest, abdomen, forearm, and thigh during rapid, local skin heating. Local temperature was set at 34 °C during baseline and increased to 39 °C, then 42 °C in 30 min increments each. Differences in %CVC<sub>max</sub> between and within age groups were evaluated at baseline, the initial vasodilator peak, and both the 39 °C and 42 °C heating plateaus.</div></div><div><h3>Results</h3><div>In young females, responses were similar across regions with the exception that %CVC<sub>max</sub> was reduced for the abdomen across heating phases relative to other regions (all <em>P</em> < 0.040). In contrast, calf responses in older females were greater compared to other regions during the 39 °C plateau only (all <em>P</em> < 0.049). %CVC<sub>max</sub> was greater at the abdomen during the 42 °C plateau (<em>P</em> = 0.022) for older females compared to young. Similarly, responses pooled across sites were significantly different (<em>P</em> = 0.035).</div></div><div><h3>Conclusion</h3><div>In our exploratory study we observed regional differences for both young and older females, and the pattern of response and the heating phases where differences occurred varied. Further, no age-related differences in %CVC<sub>max</sub> were observed apart from a marginally greater response for older females at peak heating of 42 °C. These findings highlight the need to disentangle the effects of sex and age in evaluating the vascular responses to heat and provide a critical foundation for sex-specific investigations into microvascular dysfunction.</div></div>\",\"PeriodicalId\":17428,\"journal\":{\"name\":\"Journal of thermal biology\",\"volume\":\"131 \",\"pages\":\"Article 104190\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of thermal biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0306456525001470\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of thermal biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0306456525001470","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
An exploratory assessment of regional cutaneous vasodilator responses to local heating in young and older females
Objective
To explore regional differences and potential age effects in cutaneous vascular conductance (%CVCmax) during local heating in young and older females.
Methods
In 10 young (21.4 ± 3.4 years) and 10 older (69.8 ± 2.7 years) females, %CVCmax was assessed using laser-Doppler flowmetry at the chest, abdomen, forearm, and thigh during rapid, local skin heating. Local temperature was set at 34 °C during baseline and increased to 39 °C, then 42 °C in 30 min increments each. Differences in %CVCmax between and within age groups were evaluated at baseline, the initial vasodilator peak, and both the 39 °C and 42 °C heating plateaus.
Results
In young females, responses were similar across regions with the exception that %CVCmax was reduced for the abdomen across heating phases relative to other regions (all P < 0.040). In contrast, calf responses in older females were greater compared to other regions during the 39 °C plateau only (all P < 0.049). %CVCmax was greater at the abdomen during the 42 °C plateau (P = 0.022) for older females compared to young. Similarly, responses pooled across sites were significantly different (P = 0.035).
Conclusion
In our exploratory study we observed regional differences for both young and older females, and the pattern of response and the heating phases where differences occurred varied. Further, no age-related differences in %CVCmax were observed apart from a marginally greater response for older females at peak heating of 42 °C. These findings highlight the need to disentangle the effects of sex and age in evaluating the vascular responses to heat and provide a critical foundation for sex-specific investigations into microvascular dysfunction.
期刊介绍:
The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are:
• The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature
• The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature
• Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause
• Effects of temperature on reproduction and development, growth, ageing and life-span
• Studies on modelling heat transfer between organisms and their environment
• The contributions of temperature to effects of climate change on animal species and man
• Studies of conservation biology and physiology related to temperature
• Behavioural and physiological regulation of body temperature including its pathophysiology and fever
• Medical applications of hypo- and hyperthermia
Article types:
• Original articles
• Review articles