儿童Ehlers Danlos患者阻塞性睡眠呼吸暂停及相关口咽症状的患病率

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-06-30 DOI:10.1016/j.ijporl.2025.112460

Justin Lau , David C. Kaelber , Todd D. Otteson

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引用次数: 0

摘要

目的评价Ehlers Danlos综合征（EDS）患儿的阻塞性睡眠呼吸暂停（OSA）患病率、口咽症状及手术治疗情况。研究设计回顾性队列研究。SettingTriNetX数据库。方法采用strinetx对年龄≤18岁的EDS患者进行查询。记录并报告任何发生OSA、口咽症状和腺扁桃体手术的患者。结果在10104例≤18岁的EDS患者中，652例（6.45%,95% CI: 5.99 ~ 6.95）被诊断为OSA，诊断风险是对照组（n = 17208689）的4.43倍（95% CI: 4.12 ~ 4.78）。儿童EDS患者发生吞咽困难和发音困难的风险也较高，分别为5.91 （95% CI: 5.51-6.33）和2.90 （95% CI: 2.24-3.76）。此外，与对照组相比，EDS患儿更有可能接受腺扁桃体切除术（2.51,95% CI: 2.23-2.82）。结论EDS患儿发生OSA及吞咽困难、发音困难等口咽症状的风险较高。这些患者也更有可能接受腺扁桃体手术作为纠正阻塞性睡眠呼吸暂停的一线方法。耳鼻喉科医生和语言病理学家可以在处理和治疗儿科急诊科患者口咽症状方面发挥重要的有益作用。

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Prevalence of obstructive sleep apnea and related oropharyngeal symptoms in pediatric Ehlers Danlos patients

Objective

To evaluate the prevalence of obstructive sleep apnea (OSA), oropharyngeal symptoms, and surgical OSA treatment in children with Ehlers Danlos syndrome (EDS) compared to control.

Study design

Retrospective cohort study.

Setting

TriNetX database.

Methods

TriNetX was used to query for patients ≤18 years old with and without a diagnosis of EDS. Patients with any recorded occurrence of OSA, oropharyngeal symptoms, and adenotonsillar surgeries were recorded and reported.

Results

Among 10104 patients ≤18 years old with EDS, 652 (6.45 %, 95 % CI: 5.99–6.95) had a recorded diagnosis of OSA with a 4.43 (95 % CI: 4.12–4.78) times higher risk of diagnosis compared to a control cohort (n = 17208689). Pediatric EDS patients also had a higher risk of dysphagia and dysphonia at 5.91 (95 % CI: 5.51–6.33) and 2.90 (95 % CI: 2.24–3.76), respectively. Additionally, children with EDS were more likely to undergo an adenotonsillectomy compared to control (2.51, 95 % CI: 2.23–2.82).

Conclusion

Children with EDS are at a higher risk of developing OSA and other oropharyngeal symptoms like dysphagia and dysphonia. These patients are also more likely to undergo adenotonsillar surgeries as a first-line approach to correcting obstructive sleep apnea. Otolaryngologists and speech language pathologists can play a major beneficial role in working with pediatric EDS patients in the management and treatment of oropharyngeal symptoms.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.