{"title":"前列腺素内过氧化物合酶催化花生四烯酸氧化的化学性质","authors":"Lawrence J. Marnett","doi":"10.1016/j.rbc.2025.100057","DOIUrl":null,"url":null,"abstract":"<div><div>Prostaglandins are an important class of bioactive lipids derived from arachidonic acid. The different classes of prostaglandins are produced from a common intermediate, called prostaglandin H<sub>2</sub>. Prostaglandin H<sub>2</sub> is produced by reduction of the initial oxygenation product, prostaglandin G<sub>2</sub>, which contains cyclic peroxide and hydroperoxide functionalities. Extensive experimentation has established that arachidonic acid is oxygenated to prostaglandin G<sub>2</sub> via a free radical mechanism. This review describes the key steps in the oxygenation of arachidonic acid and the evidence that supports the most widely accepted mechanism.</div></div>","PeriodicalId":101065,"journal":{"name":"Redox Biochemistry and Chemistry","volume":"13 ","pages":"Article 100057"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The chemistry of arachidonic acid oxygenation by prostaglandin endoperoxide synthase\",\"authors\":\"Lawrence J. Marnett\",\"doi\":\"10.1016/j.rbc.2025.100057\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Prostaglandins are an important class of bioactive lipids derived from arachidonic acid. The different classes of prostaglandins are produced from a common intermediate, called prostaglandin H<sub>2</sub>. Prostaglandin H<sub>2</sub> is produced by reduction of the initial oxygenation product, prostaglandin G<sub>2</sub>, which contains cyclic peroxide and hydroperoxide functionalities. Extensive experimentation has established that arachidonic acid is oxygenated to prostaglandin G<sub>2</sub> via a free radical mechanism. This review describes the key steps in the oxygenation of arachidonic acid and the evidence that supports the most widely accepted mechanism.</div></div>\",\"PeriodicalId\":101065,\"journal\":{\"name\":\"Redox Biochemistry and Chemistry\",\"volume\":\"13 \",\"pages\":\"Article 100057\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Redox Biochemistry and Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2773176625000112\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Redox Biochemistry and Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773176625000112","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The chemistry of arachidonic acid oxygenation by prostaglandin endoperoxide synthase
Prostaglandins are an important class of bioactive lipids derived from arachidonic acid. The different classes of prostaglandins are produced from a common intermediate, called prostaglandin H2. Prostaglandin H2 is produced by reduction of the initial oxygenation product, prostaglandin G2, which contains cyclic peroxide and hydroperoxide functionalities. Extensive experimentation has established that arachidonic acid is oxygenated to prostaglandin G2 via a free radical mechanism. This review describes the key steps in the oxygenation of arachidonic acid and the evidence that supports the most widely accepted mechanism.
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