{"title":"纳米颗粒治疗口腔感染性疾病的研究进展","authors":"Mitra Rostami , Pouria Farahani , Moslem Karimzadeh , Samar Esmaelian , Abbas Fadel Hussein , Kamyar Nasiri , Hareth A. Alrikabi , Naghmeh Shenasa","doi":"10.1016/j.jddst.2025.107223","DOIUrl":null,"url":null,"abstract":"<div><div>The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107223"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of theranostic nanoparticles in dental infectious diseases: A review\",\"authors\":\"Mitra Rostami , Pouria Farahani , Moslem Karimzadeh , Samar Esmaelian , Abbas Fadel Hussein , Kamyar Nasiri , Hareth A. Alrikabi , Naghmeh Shenasa\",\"doi\":\"10.1016/j.jddst.2025.107223\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders.</div></div>\",\"PeriodicalId\":15600,\"journal\":{\"name\":\"Journal of Drug Delivery Science and Technology\",\"volume\":\"112 \",\"pages\":\"Article 107223\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Drug Delivery Science and Technology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1773224725006264\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug Delivery Science and Technology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1773224725006264","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
The role of theranostic nanoparticles in dental infectious diseases: A review
The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders.
期刊介绍:
The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.