纳米颗粒治疗口腔感染性疾病的研究进展

IF 4.9 3区 医学 Q1 PHARMACOLOGY & PHARMACY
Mitra Rostami , Pouria Farahani , Moslem Karimzadeh , Samar Esmaelian , Abbas Fadel Hussein , Kamyar Nasiri , Hareth A. Alrikabi , Naghmeh Shenasa
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引用次数: 0

摘要

口腔是各种微生物的天然栖息地,其中许多微生物是致病细菌的来源,可能导致全身、局部、口腔和牙齿疾病。抗生素的过度使用、过度处方和过量导致耐药细菌的出现。由于它是一种快速和敏感的诊断,迫切需要高效和低毒的治疗方法。治疗学,即同时诊断和治疗的术语,使得纳米材料不可或缺。纳米颗粒(NPs)正在牙科领域被探索,因为它们有潜力改善牙齿感染性疾病的诊断、预防和治疗,如牙周炎、种植周炎(pi)和根管感染。它们可以增强抗菌活性,改善药物输送,提高牙科材料的有效性。此外,纳米技术的发展提高了对牙周和口腔疾病生物标志物的敏感性和快速识别。本文涵盖了牙周炎、pi和根管感染等牙齿感染性疾病的治疗和诊断。此外,研究了几种治疗性NP对牙周和口腔疾病的治疗和诊断潜力。该研究对文献的评估表明,基于纳米肿瘤学的诊断和治疗正在取得进展,以解决和减少目前广泛使用的诊断和治疗感染性牙齿疾病的技术的缺点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of theranostic nanoparticles in dental infectious diseases: A review

The role of theranostic nanoparticles in dental infectious diseases: A review
The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders.
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来源期刊
CiteScore
8.00
自引率
8.00%
发文量
879
审稿时长
94 days
期刊介绍: The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.
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