狗的桉叶:驱虫药治疗挑战和对嗅觉能力的影响

IF 2.2 2区 农林科学 Q2 PARASITOLOGY
Nathan D. Mitchell , Jenna D. Balk , Jake Hughes , Priscila Soto Nauto , Joseph Rossi , Caroline Sobotyk , Robert Valeris-Chacin , Roger Ramirez-Barrios
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引用次数: 0

摘要

鼻毛细桉近年来在兽医领域得到了越来越多的重视。然而,关于其生命周期、地理分布和治疗仍有许多未知之处。本研究旨在评价三种市售驱虫产品对猎狐犬勃氏肠杆菌的驱虫效果,并评估受感染个体的嗅觉能力。治疗方案包括莫西丁/吡虫啉(MI)和帕莫酸吡喃特/非班特/吡喹酮(PFP)单独或联合,以及莫地苷/吡喹酮(EP)单独使用。采用mini-FLOTAC技术进行粪卵计数减少试验(FECRT)以评估驱虫效果。嗅觉能力通过自然检测任务法进行评估。在第一阶段,粪蛋数减少(FECR)值在11天后处理(PT) 58 %(95 % CI: 31 % -77 %)MI, 35 %(95 % CI: 16 % -65 %)亲,和84年 %(95 % CI: 68 % -92 %)EP。第33天,所有动物的粪蛋数(FEC)均高于第0天。第一阶段研究结束一个月后,进行第二阶段试验,符合条件的动物接受MI/PFP联合治疗或单独使用EP治疗。在PT第13天,MI/PFP治疗动物的FECR为95 %(95 % CI: 78 %-100 %),EP治疗动物的FECR为89 %(95 % CI: 77 %-94 %)。虽然EP在两个阶段都表现出中等疗效,但MI和PFP产品单独无效,但一起使用时疗效很高。在嗅觉功能评估中,产蛋数与狗在测试中的表现呈中度负相关。一般来说,FEC越低,嗅觉评估的表现越好。需要进一步的研究来评估其他驱虫剂的功效,并进一步了解boehmi对狗嗅觉能力的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eucoleus boehmi in dogs: Anthelmintic treatment challenges and impact on olfactory capacity
The nasal capillarid Eucoleus boehmi has gained importance in the veterinary field in recent years. However, much is still unknown regarding its life cycle, geographic distribution, and treatment. This study aimed to evaluate the efficacy of three commercial anthelmintic products against E. boehmi in foxhound dogs and to assess the olfactory capacity of infected individuals. The treatment protocols included moxidectin/imidacloprid (MI) and pyrantel pamoate/febantel/praziquantel (PFP), separately and combined, as well as emodepside/praziquantel (EP) alone. Fecal egg count reduction tests (FECRT) were performed using the mini-FLOTAC technique for evaluating the anthelmintic efficacy. The olfactory capacity was assessed through a natural detection task method. In the first phase, the fecal egg count reduction (FECR) values at day 11 post-treatment (PT) were 58 % (95 % CI: 31 %-77 %) for MI, 35 % (95 % CI: 16 %-65 %) for PFP, and 84 % (95 % CI: 68 %-92 %) for EP. On day 33 PT, the fecal egg count (FEC) was higher in all animals compared with day 0. One month after finishing the first phase of the study, a second phase of the trial was performed, and eligible animals were treated either with a combination of MI/PFP or EP alone. On day 13 PT, FECR was 95 % (95 % CI: 78 %-100 %) in animals treated with MI/PFP and 89 % (95 % CI: 77 %-94 %) in animals that received EP. While EP demonstrated moderate efficacy in both phases, MI and PFP products were ineffective individually but achieved high efficacy when used together. In the olfactory function assessment, there was a moderate negative correlation between the egg counts and the performance of the dog in the test. In general, lower FEC were associated with better performance in the olfactory assessment. Further studies are needed to evaluate additional anthelmintics’ efficacy, and to further understand the effect of E. boehmi on a dog’s olfactory capacity.
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来源期刊
Veterinary parasitology
Veterinary parasitology 农林科学-寄生虫学
CiteScore
5.30
自引率
7.70%
发文量
126
审稿时长
36 days
期刊介绍: The journal Veterinary Parasitology has an open access mirror journal,Veterinary Parasitology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. This journal is concerned with those aspects of helminthology, protozoology and entomology which are of interest to animal health investigators, veterinary practitioners and others with a special interest in parasitology. Papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites in all domesticated animals, fall within the scope of the journal. Papers of geographically limited (local) interest which are not of interest to an international audience will not be accepted. Authors who submit papers based on local data will need to indicate why their paper is relevant to a broader readership. Parasitological studies on laboratory animals fall within the scope of the journal only if they provide a reasonably close model of a disease of domestic animals. Additionally the journal will consider papers relating to wildlife species where they may act as disease reservoirs to domestic animals, or as a zoonotic reservoir. Case studies considered to be unique or of specific interest to the journal, will also be considered on occasions at the Editors'' discretion. Papers dealing exclusively with the taxonomy of parasites do not fall within the scope of the journal.
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