Nathan D. Mitchell , Jenna D. Balk , Jake Hughes , Priscila Soto Nauto , Joseph Rossi , Caroline Sobotyk , Robert Valeris-Chacin , Roger Ramirez-Barrios
{"title":"狗的桉叶:驱虫药治疗挑战和对嗅觉能力的影响","authors":"Nathan D. Mitchell , Jenna D. Balk , Jake Hughes , Priscila Soto Nauto , Joseph Rossi , Caroline Sobotyk , Robert Valeris-Chacin , Roger Ramirez-Barrios","doi":"10.1016/j.vetpar.2025.110534","DOIUrl":null,"url":null,"abstract":"<div><div>The nasal capillarid <em>Eucoleus boehmi</em> has gained importance in the veterinary field in recent years. However, much is still unknown regarding its life cycle, geographic distribution, and treatment. This study aimed to evaluate the efficacy of three commercial anthelmintic products against <em>E. boehmi</em> in foxhound dogs and to assess the olfactory capacity of infected individuals. The treatment protocols included moxidectin/imidacloprid (MI) and pyrantel pamoate/febantel/praziquantel (PFP), separately and combined, as well as emodepside/praziquantel (EP) alone. Fecal egg count reduction tests (FECRT) were performed using the mini-FLOTAC technique for evaluating the anthelmintic efficacy. The olfactory capacity was assessed through a natural detection task method. In the first phase, the fecal egg count reduction (FECR) values at day 11 post-treatment (PT) were 58 % (95 % CI: 31 %-77 %) for MI, 35 % (95 % CI: 16 %-65 %) for PFP, and 84 % (95 % CI: 68 %-92 %) for EP. On day 33 PT, the fecal egg count (FEC) was higher in all animals compared with day 0. One month after finishing the first phase of the study, a second phase of the trial was performed, and eligible animals were treated either with a combination of MI/PFP or EP alone. On day 13 PT, FECR was 95 % (95 % CI: 78 %-100 %) in animals treated with MI/PFP and 89 % (95 % CI: 77 %-94 %) in animals that received EP. While EP demonstrated moderate efficacy in both phases, MI and PFP products were ineffective individually but achieved high efficacy when used together. In the olfactory function assessment, there was a moderate negative correlation between the egg counts and the performance of the dog in the test. In general, lower FEC were associated with better performance in the olfactory assessment. Further studies are needed to evaluate additional anthelmintics’ efficacy, and to further understand the effect of <em>E. boehmi</em> on a dog’s olfactory capacity.</div></div>","PeriodicalId":23716,"journal":{"name":"Veterinary parasitology","volume":"338 ","pages":"Article 110534"},"PeriodicalIF":2.2000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Eucoleus boehmi in dogs: Anthelmintic treatment challenges and impact on olfactory capacity\",\"authors\":\"Nathan D. Mitchell , Jenna D. Balk , Jake Hughes , Priscila Soto Nauto , Joseph Rossi , Caroline Sobotyk , Robert Valeris-Chacin , Roger Ramirez-Barrios\",\"doi\":\"10.1016/j.vetpar.2025.110534\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The nasal capillarid <em>Eucoleus boehmi</em> has gained importance in the veterinary field in recent years. However, much is still unknown regarding its life cycle, geographic distribution, and treatment. This study aimed to evaluate the efficacy of three commercial anthelmintic products against <em>E. boehmi</em> in foxhound dogs and to assess the olfactory capacity of infected individuals. The treatment protocols included moxidectin/imidacloprid (MI) and pyrantel pamoate/febantel/praziquantel (PFP), separately and combined, as well as emodepside/praziquantel (EP) alone. Fecal egg count reduction tests (FECRT) were performed using the mini-FLOTAC technique for evaluating the anthelmintic efficacy. The olfactory capacity was assessed through a natural detection task method. In the first phase, the fecal egg count reduction (FECR) values at day 11 post-treatment (PT) were 58 % (95 % CI: 31 %-77 %) for MI, 35 % (95 % CI: 16 %-65 %) for PFP, and 84 % (95 % CI: 68 %-92 %) for EP. On day 33 PT, the fecal egg count (FEC) was higher in all animals compared with day 0. One month after finishing the first phase of the study, a second phase of the trial was performed, and eligible animals were treated either with a combination of MI/PFP or EP alone. On day 13 PT, FECR was 95 % (95 % CI: 78 %-100 %) in animals treated with MI/PFP and 89 % (95 % CI: 77 %-94 %) in animals that received EP. While EP demonstrated moderate efficacy in both phases, MI and PFP products were ineffective individually but achieved high efficacy when used together. In the olfactory function assessment, there was a moderate negative correlation between the egg counts and the performance of the dog in the test. In general, lower FEC were associated with better performance in the olfactory assessment. Further studies are needed to evaluate additional anthelmintics’ efficacy, and to further understand the effect of <em>E. boehmi</em> on a dog’s olfactory capacity.</div></div>\",\"PeriodicalId\":23716,\"journal\":{\"name\":\"Veterinary parasitology\",\"volume\":\"338 \",\"pages\":\"Article 110534\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary parasitology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0304401725001451\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary parasitology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0304401725001451","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Eucoleus boehmi in dogs: Anthelmintic treatment challenges and impact on olfactory capacity
The nasal capillarid Eucoleus boehmi has gained importance in the veterinary field in recent years. However, much is still unknown regarding its life cycle, geographic distribution, and treatment. This study aimed to evaluate the efficacy of three commercial anthelmintic products against E. boehmi in foxhound dogs and to assess the olfactory capacity of infected individuals. The treatment protocols included moxidectin/imidacloprid (MI) and pyrantel pamoate/febantel/praziquantel (PFP), separately and combined, as well as emodepside/praziquantel (EP) alone. Fecal egg count reduction tests (FECRT) were performed using the mini-FLOTAC technique for evaluating the anthelmintic efficacy. The olfactory capacity was assessed through a natural detection task method. In the first phase, the fecal egg count reduction (FECR) values at day 11 post-treatment (PT) were 58 % (95 % CI: 31 %-77 %) for MI, 35 % (95 % CI: 16 %-65 %) for PFP, and 84 % (95 % CI: 68 %-92 %) for EP. On day 33 PT, the fecal egg count (FEC) was higher in all animals compared with day 0. One month after finishing the first phase of the study, a second phase of the trial was performed, and eligible animals were treated either with a combination of MI/PFP or EP alone. On day 13 PT, FECR was 95 % (95 % CI: 78 %-100 %) in animals treated with MI/PFP and 89 % (95 % CI: 77 %-94 %) in animals that received EP. While EP demonstrated moderate efficacy in both phases, MI and PFP products were ineffective individually but achieved high efficacy when used together. In the olfactory function assessment, there was a moderate negative correlation between the egg counts and the performance of the dog in the test. In general, lower FEC were associated with better performance in the olfactory assessment. Further studies are needed to evaluate additional anthelmintics’ efficacy, and to further understand the effect of E. boehmi on a dog’s olfactory capacity.
期刊介绍:
The journal Veterinary Parasitology has an open access mirror journal,Veterinary Parasitology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
This journal is concerned with those aspects of helminthology, protozoology and entomology which are of interest to animal health investigators, veterinary practitioners and others with a special interest in parasitology. Papers of the highest quality dealing with all aspects of disease prevention, pathology, treatment, epidemiology, and control of parasites in all domesticated animals, fall within the scope of the journal. Papers of geographically limited (local) interest which are not of interest to an international audience will not be accepted. Authors who submit papers based on local data will need to indicate why their paper is relevant to a broader readership.
Parasitological studies on laboratory animals fall within the scope of the journal only if they provide a reasonably close model of a disease of domestic animals. Additionally the journal will consider papers relating to wildlife species where they may act as disease reservoirs to domestic animals, or as a zoonotic reservoir. Case studies considered to be unique or of specific interest to the journal, will also be considered on occasions at the Editors'' discretion. Papers dealing exclusively with the taxonomy of parasites do not fall within the scope of the journal.