Research progress on the structure and activity of phenylpropanoid glycosides

Phenylpropanoid glycosides (PPGs) are a diverse class of naturally occurring compounds, demonstrating wide-ranging bioactivity across multiple pharmacological domains, including antioxidant, anti-inflammatory, antibacterials, anti-tumor, and platelet aggregation inhibitory effects. Composed of phenylpropanoid aglycones linked to various sugar moieties, these glycosides exhibit considerable structural diversity that influences their bioactivity. The unique structures and medicinal potential of PPGs have garnered extensive research interest. This article provides a systematic overview of recent progress in understanding the biological activities, identification of new structures and synthetic approaches of PPGs. By summarizing current findings, this review aims to support future research and development in PPG applications, particularly in the context of pharmaceutical applications.