Recent Advancements in Microfluidic Biosensors for Clinical Applications

The combination of low-consumption microfluidic chips and high-sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management. Advances in novel biomaterials have led to device integration into wearable and implantable systems for point-of-care testing. Here, we review recent advances in microfluidic biosensors for clinical applications in detecting nucleic acids, proteins, metabolites, pathogens, and cellular components. We outline the prospects of integrated devices based on microfluidic biosensors for the analysis of biofluids such as sweat and discuss the remaining challenges facing the clinical application of microfluidic biosensors.