离子液体修饰介孔二氧化硅纳米载体的高效药物传递和疏水表面工程

IF 4.7 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Annika Szymura, Shaista Ilyas, Florian Grohmann and Sanjay Mathur
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引用次数: 0

摘要

在不影响其化学特性和生物功能的情况下,实现不同分子在载体表面的共价附着仍然是一个挑战。本研究基于Menshutkin反应和铜催化的点击化学反应,合成了一种新合成的炔功能化离子液体- 1-十六烷基-3-丙炔咪唑溴化(HDPI),并将其化学吸附在叠氮修饰的介孔二氧化硅纳米载体(mSiO2,粒径为110 nm)表面。将hdpi功能化的二氧化硅纳米载体负载在四环素(TC)上,建立了一种双作用给药系统。在pH 7.4和37°C下进行的48 h时间依赖性药物释放研究显示,TC释放受到控制。表面结合离子液体(ILs)的长烷基链促进了细菌细胞壁的穿透,增强了TC在革兰氏阳性和革兰氏阴性细菌中的转运。这种双重作用机制通过抗菌试验得到验证,表明表面活性剂样IL破坏细菌细胞质膜,而抗生素诱导细胞死亡。鉴于ILs固有的抗菌性能,我们进一步研究了它们在不同环境条件下在玻璃基板上形成稳定、疏水和抗菌涂层的能力。结果表明,这些il基涂料均匀、耐用,在医疗保健和工业领域具有巨大的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ionic liquid modified mesoporous silica nanocarriers for efficient drug delivery and hydrophobic surface engineering†

Ionic liquid modified mesoporous silica nanocarriers for efficient drug delivery and hydrophobic surface engineering†

Attaining covalent attachment of diverse molecules onto carrier surfaces without compromising their chemical identity and biological functionality remains a challenge. Here, a newly synthesized alkyne-functionalized ionic liquid, 1-hexadecyl-3-propargyl imidazolium bromide (HDPI), was chemically attached on the surface of azide-modified mesoporous silica nanocarriers (mSiO2, av. size 110 nm) based on the Menshutkin reaction and copper-catalyzed click chemistry. The HDPI-functionalized mSiO2 nanocarriers were loaded with tetracycline (TC) to develop a dual-action drug delivery system. Time-dependent drug release studies conducted at pH 7.4 and 37 °C over 48 h revealed controlled TC release. The long alkyl chain of the surface-bound ionic liquids (ILs) facilitated bacterial cell wall penetration, enhancing TC transport into both Gram-positive and Gram-negative bacteria. This dual-action mechanism was validated through antibacterial assays demonstrating that the surfactant-like IL disrupts bacterial cytoplasmic membranes, while the antibiotic induces cell death. Given the inherent antibacterial properties of ILs, we further investigated their ability to form stable, hydrophobic, and antimicrobial coatings on glass substrates under different environmental conditions. The results indicate that these IL-based coatings are uniform, durable, and hold significant potential for applications in healthcare and industry.

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来源期刊
Materials Advances
Materials Advances MATERIALS SCIENCE, MULTIDISCIPLINARY-
CiteScore
7.60
自引率
2.00%
发文量
665
审稿时长
5 weeks
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