间变性淋巴瘤激酶阳性肺癌的耐药机制

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2025-06-27 DOI:10.1016/j.critrevonc.2025.104821

Parnia Behinaein , Shirish M. Gadgeel , Ramandeep Rattan , Jeffrey P. MacKeigan , Amanda Pilling , Fawzi Abu Rous , Katie R. Martin , Ikenna C. Okereke

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引用次数: 0

摘要

非小细胞肺癌已被发现具有许多独特的分子亚群，这些亚群与不同的表型行为和总体预后相关。特别是间变性淋巴瘤激酶（ALK）阳性的非小细胞肺癌（nsclc）具有独特的表现和病程。ALK非小细胞肺癌患者通常较年轻，吸烟暴露明显较少，并且通常经历较长的生存期。当患者复发时，耐药持续性（DTP）细胞可能与疾病复发有关。在这篇综述中，我们将讨论与ALK NSCLC相关的DTP现象，可能的机制解释和潜在的治疗策略来消除DTP。

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Resistance mechanisms in anaplastic lymphoma kinase-positive lung cancer

Non-small cell lung cancer has been discovered to have many unique molecular subsets that are associated with different phenotypic behaviors and overall prognoses. In particular, anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancers (NSCLCs) have distinctive presentations and disease courses. Patients with ALK NSCLC are typically younger, have significantly less smoking exposure, and often experience prolonged survival. When patients recur, drug-tolerant persister (DTP) cells may be implicated in disease recurrence. In this review we will discuss the phenomenon of DTP related to ALK NSCLC, possible mechanistic explanations and potential treatment strategies to eliminate DTPs.

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.