疟疾引起的选定微量营养素（Ca、Mg、Na、K、Zn、Fe、Co）和血浆游离氨基酸的失调；对尼日利亚人群发病机制和宿主免疫的影响

IF 2.4 Q3 INFECTIOUS DISEASES

Parasite Epidemiology and Control Pub Date : 2025-06-26 DOI:10.1016/j.parepi.2025.e00443

Chukwuma Raphael Ekeanyanwu , Paul Chidoka Chikezie , Chidinma Lynda Ekeanyanwu

{"title":"疟疾引起的选定微量营养素（Ca、Mg、Na、K、Zn、Fe、Co）和血浆游离氨基酸的失调；对尼日利亚人群发病机制和宿主免疫的影响","authors":"Chukwuma Raphael Ekeanyanwu , Paul Chidoka Chikezie , Chidinma Lynda Ekeanyanwu","doi":"10.1016/j.parepi.2025.e00443","DOIUrl":null,"url":null,"abstract":"<div><div>Malaria remains a significant global health burden, particularly in regions like Nigeria. This study investigated the impact of malaria infection on plasma amino acid and micronutrient levels in a Nigerian population. A cross-sectional study was conducted on 200 participants, including malarious and healthy controls. Plasma levels of amino acids and selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) were measured using HPLC and ICP-MS, respectively. Results revealed significant alterations (<em>p</em> < 0.01) in plasma amino acid profiles (except histidine and proline) with increasing malaria severity. Essential amino acids including branched-chain amino acids like leucine and valine were depleted, indicating metabolic disruptions in the diseases. Aromatic and immune-related amino acids (arginine, tyrosine, tryptophan, glutamine, methionine, and cysteine) were reduced significantly (<em>p</em> < 0.01) compared to the uninfected groups. Additionally, malarious individuals exhibited significant deficiencies in several micronutrients, including calcium, sodium, zinc, and iron (<em>p</em> < 0.01). Malaria infection induces a complex metabolic response, leading to nutrient imbalances that may contribute to disease severity. Further research is warranted to explore the potential of targeted nutritional interventions to improve patient outcomes.</div></div>","PeriodicalId":37873,"journal":{"name":"Parasite Epidemiology and Control","volume":"30 ","pages":"Article e00443"},"PeriodicalIF":2.4000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Malaria-induced dysregulation of selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) and plasma free amino acids; implications for pathogenesis and host immunity in a Nigerian population\",\"authors\":\"Chukwuma Raphael Ekeanyanwu , Paul Chidoka Chikezie , Chidinma Lynda Ekeanyanwu\",\"doi\":\"10.1016/j.parepi.2025.e00443\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Malaria remains a significant global health burden, particularly in regions like Nigeria. This study investigated the impact of malaria infection on plasma amino acid and micronutrient levels in a Nigerian population. A cross-sectional study was conducted on 200 participants, including malarious and healthy controls. Plasma levels of amino acids and selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) were measured using HPLC and ICP-MS, respectively. Results revealed significant alterations (<em>p</em> < 0.01) in plasma amino acid profiles (except histidine and proline) with increasing malaria severity. Essential amino acids including branched-chain amino acids like leucine and valine were depleted, indicating metabolic disruptions in the diseases. Aromatic and immune-related amino acids (arginine, tyrosine, tryptophan, glutamine, methionine, and cysteine) were reduced significantly (<em>p</em> < 0.01) compared to the uninfected groups. Additionally, malarious individuals exhibited significant deficiencies in several micronutrients, including calcium, sodium, zinc, and iron (<em>p</em> < 0.01). Malaria infection induces a complex metabolic response, leading to nutrient imbalances that may contribute to disease severity. Further research is warranted to explore the potential of targeted nutritional interventions to improve patient outcomes.</div></div>\",\"PeriodicalId\":37873,\"journal\":{\"name\":\"Parasite Epidemiology and Control\",\"volume\":\"30 \",\"pages\":\"Article e00443\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parasite Epidemiology and Control\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405673125000364\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parasite Epidemiology and Control","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405673125000364","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

疟疾仍然是一个重大的全球卫生负担，特别是在尼日利亚等地区。本研究调查了疟疾感染对尼日利亚人群血浆氨基酸和微量营养素水平的影响。对200名参与者进行了横断面研究，包括疟疾和健康对照。分别用高效液相色谱法和ICP-MS法测定血浆中氨基酸和选定微量营养素（Ca、Mg、Na、K、Zn、Fe、Co）的含量。结果显示显著改变(p <；血浆氨基酸谱（组氨酸和脯氨酸除外）随疟疾严重程度的增加而增加。必需氨基酸，包括支链氨基酸，如亮氨酸和缬氨酸，都被耗尽了，这表明疾病的代谢中断。芳香和免疫相关的氨基酸（精氨酸、酪氨酸、色氨酸、谷氨酰胺、蛋氨酸和半胱氨酸）显著减少(p <；0.01)。此外，疟疾个体表现出几种微量营养素的显著缺乏，包括钙、钠、锌和铁(p <；0.01)。疟疾感染引起复杂的代谢反应，导致营养失衡，从而可能导致疾病的严重程度。需要进一步的研究来探索有针对性的营养干预以改善患者预后的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Malaria-induced dysregulation of selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) and plasma free amino acids; implications for pathogenesis and host immunity in a Nigerian population

Malaria remains a significant global health burden, particularly in regions like Nigeria. This study investigated the impact of malaria infection on plasma amino acid and micronutrient levels in a Nigerian population. A cross-sectional study was conducted on 200 participants, including malarious and healthy controls. Plasma levels of amino acids and selected micronutrients (Ca, Mg, Na, K, Zn, Fe, Co) were measured using HPLC and ICP-MS, respectively. Results revealed significant alterations (p < 0.01) in plasma amino acid profiles (except histidine and proline) with increasing malaria severity. Essential amino acids including branched-chain amino acids like leucine and valine were depleted, indicating metabolic disruptions in the diseases. Aromatic and immune-related amino acids (arginine, tyrosine, tryptophan, glutamine, methionine, and cysteine) were reduced significantly (p < 0.01) compared to the uninfected groups. Additionally, malarious individuals exhibited significant deficiencies in several micronutrients, including calcium, sodium, zinc, and iron (p < 0.01). Malaria infection induces a complex metabolic response, leading to nutrient imbalances that may contribute to disease severity. Further research is warranted to explore the potential of targeted nutritional interventions to improve patient outcomes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Parasite Epidemiology and Control Medicine-Infectious Diseases

CiteScore

5.70

自引率

3.10%

发文量

审稿时长

17 weeks

期刊介绍： Parasite Epidemiology and Control is an Open Access journal. There is an increasing amount of research in the parasitology area that analyses the patterns, causes, and effects of health and disease conditions in defined populations. This epidemiology of parasite infectious diseases is predominantly studied in human populations but also spans other major hosts of parasitic infections and as such this journal will have a broad remit. We will focus on the major areas of epidemiological study including disease etiology, disease surveillance, drug resistance and geographical spread and screening, biomonitoring, and comparisons of treatment effects in clinical trials for both human and other animals. We will also look at the epidemiology and control of vector insects. The journal will also cover the use of geographic information systems (Epi-GIS) for epidemiological surveillance which is a rapidly growing area of research in infectious diseases. Molecular epidemiological approaches are also particularly encouraged.