颗粒形状对含银生物玻璃/壳聚糖涂层抑菌效果及生物活性的影响

IF 7.3 2区材料科学 Q1 CHEMISTRY, APPLIED

Progress in Organic Coatings Pub Date : 2025-07-01 DOI:10.1016/j.porgcoat.2025.109484

Ching-Chien Huang , Han-Ting Lin , Ming-Hong Lin , Shih-Fu Ou

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引用次数: 0

摘要

在聚合物基涂层中包裹含银颗粒可以控制银离子的释放，在不影响细胞相容性的情况下提高钛合金的抗菌活性。然而，完全包封含银颗粒将消除其抗菌作用。本研究合成了均匀粒径的含银生物玻璃（AgBG），并开发了AgBG/壳聚糖涂层，以提高Ti的抗菌性能和生物活性。采用Stöber和溶胶-凝胶法制备了球形和不规则形状的AgBG颗粒。研究了两种AgBG对涂层表面特性、抗菌活性和生物活性的影响。结果表明：Stöber-method AgBG颗粒均匀分散在涂层中，表面暴露较多，具有良好的抗菌活性（90.2%）、生物活性和附着力（ASTM 5B）。相反，溶胶-凝胶法的AgBG颗粒暴露在涂层上形成大的聚集体，导致附着力差（ASTM 4B）。此外，通过溶胶-凝胶法合成的AgBG颗粒涂层需要高浓度才能表现出抗菌性能。综上所述，AgBG颗粒几何形状显著影响AgBG/壳聚糖涂层内的颗粒分布，而颗粒分布反过来又强烈影响涂层的表面性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Influence of particle shape on antibacterial efficacy and bioactivity of Ag-containing bioglass/chitosan coatings on Ti

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Influence of particle shape on antibacterial efficacy and bioactivity of Ag-containing bioglass/chitosan coatings on Ti

Encapsulating Ag-containing particles within polymer-based coatings can control Ag-ion release, improving the antibacterial activity of Ti alloys without compromising cytocompatibility. However, complete encapsulation of the Ag-containing particles will eliminate its antibacterial effects. This study synthesized uniformly sized Ag-containing bioglass (AgBG) and developed AgBG/chitosan coatings to enhance the antibacterial properties and bioactivity of Ti. Spherical and irregularly shaped AgBG particles were synthesized using Stöber and sol-gel methods. The effects of the two types of AgBG on the surface characteristics, antibacterial activity, and bioactivity of the coatings were investigated. Results showed that Stöber-method AgBG particles were evenly dispersed in the coating, with many particles exposed on the surface, leading to good antibacterial activity (90.2 %), bioactivity, and adhesion (ASTM 5B). Conversely, sol-gel-method AgBG particles formed large aggregates exposed to the coating, resulting in poor adhesion (ASTM 4B). Furthermore, the coating with AgBG particles synthesized by the sol-gel method required a high concentration to exhibit antibacterial properties. In summary, the AgBG particle geometry significantly influences particle distribution within the AgBG/chitosan coating, which, in turn, strongly affects the surface properties of the coating.

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来源期刊

Progress in Organic Coatings 工程技术-材料科学：膜

CiteScore

11.40

自引率

15.20%

发文量

577

审稿时长

48 days

期刊介绍： The aim of this international journal is to analyse and publicise the progress and current state of knowledge in the field of organic coatings and related materials. The Editors and the Editorial Board members will solicit both review and research papers from academic and industrial scientists who are actively engaged in research and development or, in the case of review papers, have extensive experience in the subject to be reviewed. Unsolicited manuscripts will be accepted if they meet the journal''s requirements. The journal publishes papers dealing with such subjects as: • Chemical, physical and technological properties of organic coatings and related materials • Problems and methods of preparation, manufacture and application of these materials • Performance, testing and analysis.