PKM2：脂质代谢的新舵手

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-06-27 DOI:10.1016/j.cellsig.2025.111967

Zhijun Liu, Yifei Le, Dezhao Lu

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引用次数: 0

摘要

PKM2是丙酮酸激酶的一种异构体，催化活性低，在快速增殖的细胞中大量存在。大量研究证明PKM2在癌症、非酒精性脂肪性肝病、动脉粥样硬化等脂质代谢异常等疾病中的重要作用。本文综述了PKM2在脂质代谢不同途径中的作用，并提出PKM2可能是脂质代谢紊乱的潜在治疗靶点。此外，本文还介绍了常见的PKM2干预方式，旨在为靶向PKM2治疗脂质代谢紊乱相关疾病提供新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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PKM2: A novel helmsman of lipid metabolism

PKM2 is an isoform of pyruvate kinase, which has low catalytic activity and is abundantly present in rapidly proliferating cells. Numerous studies have demonstrated the important role of PKM2 in diseases such as cancer, non-alcoholic fatty liver disease, atherosclerosis and other abnormalities of lipid metabolism. In this paper, we review the roles played by PKM2 in different pathways of lipid metabolism, and suggest that PKM2 may be a potential therapeutic target in disorders of lipid metabolism. In addition, this review introduces common PKM2 intervention modalities, aiming to provide new possibilities for targeting PKM2 in the treatment of lipid metabolism disorders-related diseases.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.