疫苗的当前和未来前景:保护人类免受新发和再发传染病的侵害

IF 1.4 4区 医学 Q4 IMMUNOLOGY
Basavaraj Neelappa Gonal , Nagarjuna Prakash Dalbanjan , Arihant Jayawant Kadapure , K.R. Shubham , S.K. Praveen Kumar , Suresh B. Arakera
{"title":"疫苗的当前和未来前景:保护人类免受新发和再发传染病的侵害","authors":"Basavaraj Neelappa Gonal ,&nbsp;Nagarjuna Prakash Dalbanjan ,&nbsp;Arihant Jayawant Kadapure ,&nbsp;K.R. Shubham ,&nbsp;S.K. Praveen Kumar ,&nbsp;Suresh B. Arakera","doi":"10.1016/j.ijmmb.2025.100908","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>Vaccines have proven to be one of the most effective tools for controlling infectious diseases worldwide, significantly lowering illness and death rates caused by various pathogens. However, the emergence of new and re-emerging infectious diseases highlights the critical need for advanced vaccine technologies that can respond to dynamic, evolving health threats.</div></div><div><h3>Discussion</h3><div>This review examines recent advances in vaccine science, with a particular emphasis on the development of next-generation platforms such as mRNA and viral vector-based vaccines, as well as advancements in formulation and delivery systems. These advances have helped overcome immune escape mechanisms, which pathogens use to avoid immune detection and reduce vaccine efficacy. The review provides an historical perspective showing how each breakthrough has influenced current strategies, such as those used during the COVID-19 pandemic, and how cumulative progress has shaped today's rapid vaccine development and deployment capabilities.</div></div><div><h3>Conclusion</h3><div>Lessons from recent vaccine innovations, combined with historical perspectives, point to a bright future in which pathogen-specific vaccine designs, personalized immune responses, and global access will all play important roles in public health. Together, these findings lay the groundwork for future progress in pandemic preparedness and global health security.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"56 ","pages":"Article 100908"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Present and future prospects of vaccines: protecting humanity against emerging and re-emerging infectious diseases\",\"authors\":\"Basavaraj Neelappa Gonal ,&nbsp;Nagarjuna Prakash Dalbanjan ,&nbsp;Arihant Jayawant Kadapure ,&nbsp;K.R. Shubham ,&nbsp;S.K. Praveen Kumar ,&nbsp;Suresh B. Arakera\",\"doi\":\"10.1016/j.ijmmb.2025.100908\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>Vaccines have proven to be one of the most effective tools for controlling infectious diseases worldwide, significantly lowering illness and death rates caused by various pathogens. However, the emergence of new and re-emerging infectious diseases highlights the critical need for advanced vaccine technologies that can respond to dynamic, evolving health threats.</div></div><div><h3>Discussion</h3><div>This review examines recent advances in vaccine science, with a particular emphasis on the development of next-generation platforms such as mRNA and viral vector-based vaccines, as well as advancements in formulation and delivery systems. These advances have helped overcome immune escape mechanisms, which pathogens use to avoid immune detection and reduce vaccine efficacy. The review provides an historical perspective showing how each breakthrough has influenced current strategies, such as those used during the COVID-19 pandemic, and how cumulative progress has shaped today's rapid vaccine development and deployment capabilities.</div></div><div><h3>Conclusion</h3><div>Lessons from recent vaccine innovations, combined with historical perspectives, point to a bright future in which pathogen-specific vaccine designs, personalized immune responses, and global access will all play important roles in public health. Together, these findings lay the groundwork for future progress in pandemic preparedness and global health security.</div></div>\",\"PeriodicalId\":13284,\"journal\":{\"name\":\"Indian Journal of Medical Microbiology\",\"volume\":\"56 \",\"pages\":\"Article 100908\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Medical Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0255085725001215\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0255085725001215","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

疫苗已被证明是世界范围内控制传染病最有效的工具之一,可显著降低由各种病原体引起的发病率和死亡率。然而,新的和重新出现的传染病的出现突出表明,迫切需要能够应对动态的、不断变化的健康威胁的先进疫苗技术。本文回顾了疫苗科学的最新进展,特别强调下一代平台的发展,如mRNA和基于病毒载体的疫苗,以及配方和递送系统的进展。这些进展有助于克服免疫逃逸机制,病原体利用免疫逃逸机制避免免疫检测并降低疫苗效力。回顾从历史的角度展示了每一项突破如何影响当前的战略,例如在2019冠状病毒病大流行期间使用的战略,以及累积进展如何塑造了当今快速疫苗开发和部署的能力。最近疫苗创新的经验教训,结合历史观点,指出了一个光明的未来,即病原体特异性疫苗设计、个性化免疫反应和全球可及性都将在公共卫生中发挥重要作用。总之,这些发现为未来在大流行防范和全球卫生安全方面取得进展奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Present and future prospects of vaccines: protecting humanity against emerging and re-emerging infectious diseases

Present and future prospects of vaccines: protecting humanity against emerging and re-emerging infectious diseases

Introduction

Vaccines have proven to be one of the most effective tools for controlling infectious diseases worldwide, significantly lowering illness and death rates caused by various pathogens. However, the emergence of new and re-emerging infectious diseases highlights the critical need for advanced vaccine technologies that can respond to dynamic, evolving health threats.

Discussion

This review examines recent advances in vaccine science, with a particular emphasis on the development of next-generation platforms such as mRNA and viral vector-based vaccines, as well as advancements in formulation and delivery systems. These advances have helped overcome immune escape mechanisms, which pathogens use to avoid immune detection and reduce vaccine efficacy. The review provides an historical perspective showing how each breakthrough has influenced current strategies, such as those used during the COVID-19 pandemic, and how cumulative progress has shaped today's rapid vaccine development and deployment capabilities.

Conclusion

Lessons from recent vaccine innovations, combined with historical perspectives, point to a bright future in which pathogen-specific vaccine designs, personalized immune responses, and global access will all play important roles in public health. Together, these findings lay the groundwork for future progress in pandemic preparedness and global health security.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.20
自引率
0.00%
发文量
154
审稿时长
73 days
期刊介绍: Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信