碎片状和球形微塑料对海洋轮虫韩国臂轮虫的比较影响:多代慢性毒性和多组学观点

IF 11.3 1区 环境科学与生态学 Q1 ENGINEERING, ENVIRONMENTAL
Je-Won Yoo, Tae-June Choi, Jong-Seok Park, Youn-Ha Lee, Da Hyeon Hwang, Chang-Bae Kim, Tae-Yong Jeong, Young-Mi Lee
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引用次数: 0

摘要

本研究研究了不同大小和形状的微塑料(MPs)在个体和分子水平上对海洋轮虫韩国臂轮虫的毒性作用。一项多代慢性毒性试验表明,只有小片段MPs (fragment-S)显著降低轮虫的繁殖力和寿命,并在后代中增强。暴露于片段- s组的轮虫转录组调节最为显著,其次是暴露于大片段(片段- l)、小珠子(珠子- s)和大珠子(珠子- l)的轮虫。然而,仅在暴露于碎片MPs (fragment-S >;片段- l),表明形状是决定MPs毒性的一个比大小更关键的因素。与能量代谢相关的途径通常受到MP暴露的影响,而与转录、神经系统和翻译相关的不同基因主要受到特定MP类型的影响,这表明MP的毒性机制依赖于大小和形状。总的来说,我们的研究结果表明,MPs的分子毒性机制取决于它们的大小和形状,强调物理性质是决定MPs毒性的主要因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative impacts of fragmented versus spherical microplastics on the marine rotifer Brachionus koreanus: multigenerational chronic toxicity and multi-omics perspective
This study investigated the toxic effects of microplastics (MPs) of different sizes and shapes on the marine rotifer, Brachionus koreanus, at both the individual and molecular levels. A multigenerational chronic toxicity test showed that only small fragmented MPs (fragment-S) significantly reduced the fecundity and lifespan of rotifers, which was enhanced in subsequent generations. Transcriptomic modulation of rotifers was most significant in the group exposed to fragment-S, followed by those exposed to large fragments (fragment-L), small beads (bead-S), and large beads (bead-L). However, significant metabolomic perturbation was detected only in the group exposed to fragmented MPs (fragment-S > fragment-L), suggesting that shape is a more critical factor than size in determining the toxicity of MPs. Pathways related to energy metabolism were commonly affected by MP exposure, whereas different genes related to transcription, the nervous system, and translation were primarily affected by specific MP types, indicating size- and shape-dependent toxic mechanisms of MPs. Overall, our findings suggest that the molecular toxicity mechanisms of MPs depend on their size and shape, highlighting that physical properties are a major factor in determining the toxicity of MPs.
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来源期刊
Journal of Hazardous Materials
Journal of Hazardous Materials 工程技术-工程:环境
CiteScore
25.40
自引率
5.90%
发文量
3059
审稿时长
58 days
期刊介绍: The Journal of Hazardous Materials serves as a global platform for promoting cutting-edge research in the field of Environmental Science and Engineering. Our publication features a wide range of articles, including full-length research papers, review articles, and perspectives, with the aim of enhancing our understanding of the dangers and risks associated with various materials concerning public health and the environment. It is important to note that the term "environmental contaminants" refers specifically to substances that pose hazardous effects through contamination, while excluding those that do not have such impacts on the environment or human health. Moreover, we emphasize the distinction between wastes and hazardous materials in order to provide further clarity on the scope of the journal. We have a keen interest in exploring specific compounds and microbial agents that have adverse effects on the environment.
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