颞叶癫痫的个性化功能和结构语言偏侧及其对记忆的影响

IF 3.5 2区 医学 Q1 NEUROIMAGING
Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy
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引用次数: 0

摘要

大脑功能不对称的基础和影响,特别是语言偏侧,还没有被完全理解,功能和结构不对称之间的关系在很大程度上仍未得到检验。本研究探讨了脑半球语言侧性不对称与脑灰质结构不对称的一致性程度,以及脑半球记忆组织是否受到功能性语言不对称的影响。从261名个体中获得结构和功能MR数据,包括单侧颞叶癫痫患者(LTLE = 96, RTLE = 69)和健康参与者(HPs = 96)。使用两种方法计算功能性语言侧性指数(LIs):(1)来自额叶、颞叶和顶叶的标准LIs;(2)来自单独定义的激活峰的目标LIs (T-LIs)。结构LIs (ST-LIs)来源于这些功能性li下面的GM体积。我们观察到,在12个大脑区域中,有8个区域与HPs相比,LTLE的语言侧性发生了显著变化。在功能性li和结构对应物之间观察到很强的相关性。判别分析表明,靶向LIs和ST-LIs能更有效地区分TLE患者和hp患者,其中ST-LIs是最有效的鉴别因子。偏最小二乘分析显示,言语和视觉记忆直接依赖于HPs和LTLE中的靶向li,这种影响在HPs中更为明显。在RTLE中,言语记忆也表现出类似的依赖性。这些发现强调了理解语言侧性的个性化、区域特异性措施的重要性,以及它与结构基础的关系,以及它对其他认知功能(如记忆)组织的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory

Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory

The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated using two methods: (1) standard LIs from the frontal, temporal, and parietal lobes and (2) targeted LIs (T-LIs) from individually defined activation peaks. Structural LIs (ST-LIs) were derived from the GM volumes underlying these functional LIs. We observed significant shifts in language laterality in LTLE compared to HPs in 8 out of 12 brain regions. Strong correlations were observed between functional LIs and their structural counterparts. Discriminant analyses demonstrated that targeted LIs and ST-LIs more effectively distinguished TLE patients from HPs, with ST-LIs being the most powerful discriminator. Partial least squares analyses showed verbal and visual memory have a direct dependence on targeted LIs in HPs and LTLE, with this effect more pronounced in HPs. In RTLE, verbal memory showed a similar dependency. These findings underscored the importance of individualized, region-specific measures for understanding language laterality, its relation to structural underpinnings, and its impact on the organization of other cognitive functions such as memory.

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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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