Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy
{"title":"颞叶癫痫的个性化功能和结构语言偏侧及其对记忆的影响","authors":"Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy","doi":"10.1002/hbm.70250","DOIUrl":null,"url":null,"abstract":"<p>The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated using two methods: (1) standard LIs from the frontal, temporal, and parietal lobes and (2) targeted LIs (T-LIs) from individually defined activation peaks. Structural LIs (ST-LIs) were derived from the GM volumes underlying these functional LIs. We observed significant shifts in language laterality in LTLE compared to HPs in 8 out of 12 brain regions. Strong correlations were observed between functional LIs and their structural counterparts. Discriminant analyses demonstrated that targeted LIs and ST-LIs more effectively distinguished TLE patients from HPs, with ST-LIs being the most powerful discriminator. Partial least squares analyses showed verbal and visual memory have a direct dependence on targeted LIs in HPs and LTLE, with this effect more pronounced in HPs. In RTLE, verbal memory showed a similar dependency. These findings underscored the importance of individualized, region-specific measures for understanding language laterality, its relation to structural underpinnings, and its impact on the organization of other cognitive functions such as memory.</p>","PeriodicalId":13019,"journal":{"name":"Human Brain Mapping","volume":"46 10","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hbm.70250","citationCount":"0","resultStr":"{\"title\":\"Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory\",\"authors\":\"Ankeeta Ankeeta, Qirui Zhang, Sam Sharifzadeh Javidi, Shilpi Modi, Michael R. Sperling, Joseph I. Tracy\",\"doi\":\"10.1002/hbm.70250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated using two methods: (1) standard LIs from the frontal, temporal, and parietal lobes and (2) targeted LIs (T-LIs) from individually defined activation peaks. Structural LIs (ST-LIs) were derived from the GM volumes underlying these functional LIs. We observed significant shifts in language laterality in LTLE compared to HPs in 8 out of 12 brain regions. Strong correlations were observed between functional LIs and their structural counterparts. Discriminant analyses demonstrated that targeted LIs and ST-LIs more effectively distinguished TLE patients from HPs, with ST-LIs being the most powerful discriminator. Partial least squares analyses showed verbal and visual memory have a direct dependence on targeted LIs in HPs and LTLE, with this effect more pronounced in HPs. In RTLE, verbal memory showed a similar dependency. 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Individualized Functional and Structural Language Lateralities in Temporal Lobe Epilepsy and Their Impact on Memory
The basis and impact of functional asymmetries in the brain, particularly language lateralization, are not fully understood, and the relationship between functional and structural asymmetries remains largely untested. This study investigated the degree to which asymmetries in hemispheric language laterality are concordant with asymmetries in gray matter (GM) structure and whether the hemispheric organization of memory is influenced by functional language asymmetries. Structural and functional MR data was acquired from 261 individuals, including those with unilateral temporal lobe epilepsy (LTLE = 96, RTLE = 69) and matched with healthy participants (HPs = 96). Functional language laterality indices (LIs) were calculated using two methods: (1) standard LIs from the frontal, temporal, and parietal lobes and (2) targeted LIs (T-LIs) from individually defined activation peaks. Structural LIs (ST-LIs) were derived from the GM volumes underlying these functional LIs. We observed significant shifts in language laterality in LTLE compared to HPs in 8 out of 12 brain regions. Strong correlations were observed between functional LIs and their structural counterparts. Discriminant analyses demonstrated that targeted LIs and ST-LIs more effectively distinguished TLE patients from HPs, with ST-LIs being the most powerful discriminator. Partial least squares analyses showed verbal and visual memory have a direct dependence on targeted LIs in HPs and LTLE, with this effect more pronounced in HPs. In RTLE, verbal memory showed a similar dependency. These findings underscored the importance of individualized, region-specific measures for understanding language laterality, its relation to structural underpinnings, and its impact on the organization of other cognitive functions such as memory.
期刊介绍:
Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged.
Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.