Frontispiece: Ultra-Stable Gold Nanoparticles with Tunable Surface Characteristics

Ultra-stable gold nanoparticles, achieved via in situ free-radical polymerization, are reported by B. Xu et al. in their Communication (e202507954). The crosslinked polymer shell surrounding the nanoparticles enhances their stability and enables tunable surface functionalities, resulting in prolonged circulation in the bloodstream and improved tumor targeting in mice. These findings underscore their promising potential as leading candidates for gold-based nanomedical applications.