{"title":"富白细胞-血小板纤维蛋白(L-PRF)塞加速年轻人上颌犬后缩的疗效:一项裂口随机对照试验","authors":"A. Iswariya , Ashok Kumar Jena , Manaswini Mangaraj , Jitendra Sharan , Gautom Kumar Saharia","doi":"10.1016/j.jobcr.2025.06.023","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effect of the L-PRF plug on the rate of maxillary canine retraction during the comprehensive orthodontic treatment.</div></div><div><h3>Materials and methods</h3><div>The present split-mouth randomized controlled trial included 15 female patients (age range, 18–25 yrs) requiring all 1st premolars extraction for correction of their malocclusion. Right and left sides of the maxillary arch in each patient were randomly allocated to control and experimental sides. Simultaneous canine retraction was initiated immediately after the extraction of 1st premolars on the control side, and placement of L-PRF plugs on the experimental side 1st premolar extraction socket. The amount of canine retraction was evaluated from 3D models of the maxillary study models prepared immediately before (T<sub>0</sub>), then at 1 week (T<sub>1</sub>), 2 weeks (T<sub>2</sub>), 4 weeks (T<sub>3</sub>), and 8 weeks (T<sub>4</sub>) after the extraction of first premolars and placement of L-PRF. The concentration of IL-6 in the GCF was estimated at T<sub>0</sub>, T<sub>1</sub>, T<sub>2</sub>, T<sub>3</sub>, and T<sub>4</sub>.</div></div><div><h3>Results</h3><div>Of 15 enrolled, one participant lost during the follow-up. The data of fourteen maxillary arches (14 experimental and 14 control sides) were analyzed. During the first four weeks of observation, the experimental sides had more canine retraction of 0.25 mm (P = 0.001). The mean concentrations of IL-6 at mesial and distal aspects of experimental and control side canines were comparable (P > 0.05). There was a significant increase in IL-6 concentration in the distal compared to the mesial aspects of canine in experimental sides at T<sub>1</sub> (P = 0.004) and T<sub>2</sub> (P = 0.030). There was no correlation between the IL-6 levels and the amount of canine retraction. No adverse effects to any patient were observed during the eight weeks study period.</div></div><div><h3>Conclusion</h3><div>Although the application of L-PRF accelerated the maxillary canine retraction by 0.32 mm throughout the eight weeks, with most of the acceleration occurring in the first four weeks, but it was not clinically significant in decreasing the total duration of orthodontic treatment.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 5","pages":"Pages 963-970"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Efficacy of leukocyte-platelet rich fibrin (L-PRF) plug in accelerating the maxillary canine retraction in young adults: A split mouth randomized controlled trial\",\"authors\":\"A. Iswariya , Ashok Kumar Jena , Manaswini Mangaraj , Jitendra Sharan , Gautom Kumar Saharia\",\"doi\":\"10.1016/j.jobcr.2025.06.023\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><div>To evaluate the effect of the L-PRF plug on the rate of maxillary canine retraction during the comprehensive orthodontic treatment.</div></div><div><h3>Materials and methods</h3><div>The present split-mouth randomized controlled trial included 15 female patients (age range, 18–25 yrs) requiring all 1st premolars extraction for correction of their malocclusion. Right and left sides of the maxillary arch in each patient were randomly allocated to control and experimental sides. Simultaneous canine retraction was initiated immediately after the extraction of 1st premolars on the control side, and placement of L-PRF plugs on the experimental side 1st premolar extraction socket. The amount of canine retraction was evaluated from 3D models of the maxillary study models prepared immediately before (T<sub>0</sub>), then at 1 week (T<sub>1</sub>), 2 weeks (T<sub>2</sub>), 4 weeks (T<sub>3</sub>), and 8 weeks (T<sub>4</sub>) after the extraction of first premolars and placement of L-PRF. The concentration of IL-6 in the GCF was estimated at T<sub>0</sub>, T<sub>1</sub>, T<sub>2</sub>, T<sub>3</sub>, and T<sub>4</sub>.</div></div><div><h3>Results</h3><div>Of 15 enrolled, one participant lost during the follow-up. The data of fourteen maxillary arches (14 experimental and 14 control sides) were analyzed. During the first four weeks of observation, the experimental sides had more canine retraction of 0.25 mm (P = 0.001). The mean concentrations of IL-6 at mesial and distal aspects of experimental and control side canines were comparable (P > 0.05). There was a significant increase in IL-6 concentration in the distal compared to the mesial aspects of canine in experimental sides at T<sub>1</sub> (P = 0.004) and T<sub>2</sub> (P = 0.030). There was no correlation between the IL-6 levels and the amount of canine retraction. No adverse effects to any patient were observed during the eight weeks study period.</div></div><div><h3>Conclusion</h3><div>Although the application of L-PRF accelerated the maxillary canine retraction by 0.32 mm throughout the eight weeks, with most of the acceleration occurring in the first four weeks, but it was not clinically significant in decreasing the total duration of orthodontic treatment.</div></div>\",\"PeriodicalId\":16609,\"journal\":{\"name\":\"Journal of oral biology and craniofacial research\",\"volume\":\"15 5\",\"pages\":\"Pages 963-970\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of oral biology and craniofacial research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212426825001423\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of oral biology and craniofacial research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212426825001423","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Efficacy of leukocyte-platelet rich fibrin (L-PRF) plug in accelerating the maxillary canine retraction in young adults: A split mouth randomized controlled trial
Objective
To evaluate the effect of the L-PRF plug on the rate of maxillary canine retraction during the comprehensive orthodontic treatment.
Materials and methods
The present split-mouth randomized controlled trial included 15 female patients (age range, 18–25 yrs) requiring all 1st premolars extraction for correction of their malocclusion. Right and left sides of the maxillary arch in each patient were randomly allocated to control and experimental sides. Simultaneous canine retraction was initiated immediately after the extraction of 1st premolars on the control side, and placement of L-PRF plugs on the experimental side 1st premolar extraction socket. The amount of canine retraction was evaluated from 3D models of the maxillary study models prepared immediately before (T0), then at 1 week (T1), 2 weeks (T2), 4 weeks (T3), and 8 weeks (T4) after the extraction of first premolars and placement of L-PRF. The concentration of IL-6 in the GCF was estimated at T0, T1, T2, T3, and T4.
Results
Of 15 enrolled, one participant lost during the follow-up. The data of fourteen maxillary arches (14 experimental and 14 control sides) were analyzed. During the first four weeks of observation, the experimental sides had more canine retraction of 0.25 mm (P = 0.001). The mean concentrations of IL-6 at mesial and distal aspects of experimental and control side canines were comparable (P > 0.05). There was a significant increase in IL-6 concentration in the distal compared to the mesial aspects of canine in experimental sides at T1 (P = 0.004) and T2 (P = 0.030). There was no correlation between the IL-6 levels and the amount of canine retraction. No adverse effects to any patient were observed during the eight weeks study period.
Conclusion
Although the application of L-PRF accelerated the maxillary canine retraction by 0.32 mm throughout the eight weeks, with most of the acceleration occurring in the first four weeks, but it was not clinically significant in decreasing the total duration of orthodontic treatment.
期刊介绍:
Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.