Accelerometer-derived concentrated physical activity pattern and mortality in cancer survivors: the UK Biobank accelerometry study.

Although reduced mortality associated with moderate-to-vigorous physical activity (MVPA) has been reported among cancer survivors, the benefits of a concentrated PA pattern remain unclear. This prospective cohort study included 6,075 cancer survivors from the UK Biobank accelerometry dataset: 2,390 (39.3%) were inactive (< 150 minutes/week), 1,295 (21.3%) were active concentrated (≥ 150 minutes/week and achieved ≥ 50% total MVPA within 1-2 days), and 2,390 (39.3%) were active regular (≥ 150 minutes/week, but other than concentrated). After a median follow-up of 8 years (interquartile range, 7.5-8.5), 634 deaths occurred. Both active concentrated and regular patterns were associated with reduced all-cause mortality (HR 0.72 [95% CI, 0.60-0.86]; HR 0.71 [95% CI, 0.56-0.89]) and non-cancer mortality (HR 0.66 [95% CI, 0.47-0.92]; HR 0.56 [95% CI, 0.35-0.89]). These findings highlight the concentrated PA pattern as a lifestyle intervention for cancer survivors.