{"title":"主动脉狭窄与视神经病变的相关性：一项基于人群的队列研究","authors":"Chia-Yi Lee, Shun-Fa Yang, Elsa Lin-Chin Mai, Jing-Yang Huang, Chao-Bin Yeh, Chao-Kai Chang","doi":"10.21873/invivo.14009","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>To survey the potential correlation between aortic stenosis (AS) and subsequent optic neuropathies of glaucoma and ischemic optic neuropathy.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted with the use of the TriNetX database, a project by the US Collaborative Network which enrolled 68 healthcare institutions. PSM There were 426,980 and 426,980 people divided into the AS and non-AS groups after exclusion. The primary outcomes were the development of glaucoma and ischemic optic neuropathy. Cox proportional hazard regression was used to produce the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of the optic neuropathies between groups.</p><p><strong>Results: </strong>There were 11,717 and 8,676 glaucoma episodes found in the AS and no-AS groups, and there were 566 and 391 ischemic optic neuropathy episodes found in the AS and no-AS groups. The AS group had a significantly higher risk of glaucoma (aHR=1.277, 95% CI=1.242-1.312, <i>p</i><0.001) and ischemic optic neuropathy (aHR=1.362, 95% CI=1.197-1.549, <i>p</i><0.001) compared to the non-AS population. The cumulative probability of glaucoma and ischemic optic neuropathy were significantly higher in the AS group than the non-AS group (both <i>p</i><0.001). In the multivariate analysis, the incidence of ischemic optic neuropathy was significantly higher in the AS group compared to that of the non-AS group with different characteristics except in those with Asian race, aged 20-44 years old, and aged 65-80 years old (all 95% CIs included 1).</p><p><strong>Conclusion: </strong>The existence of AS correlates to higher risk of developing glaucoma and ischemic optic neuropathy.</p>","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 4","pages":"2133-2143"},"PeriodicalIF":1.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223618/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Correlation Between Aortic Stenosis and the Subsequent Incidence of Optic Neuropathy: A Population-based Cohort Study.\",\"authors\":\"Chia-Yi Lee, Shun-Fa Yang, Elsa Lin-Chin Mai, Jing-Yang Huang, Chao-Bin Yeh, Chao-Kai Chang\",\"doi\":\"10.21873/invivo.14009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>To survey the potential correlation between aortic stenosis (AS) and subsequent optic neuropathies of glaucoma and ischemic optic neuropathy.</p><p><strong>Patients and methods: </strong>A retrospective cohort study was conducted with the use of the TriNetX database, a project by the US Collaborative Network which enrolled 68 healthcare institutions. PSM There were 426,980 and 426,980 people divided into the AS and non-AS groups after exclusion. The primary outcomes were the development of glaucoma and ischemic optic neuropathy. Cox proportional hazard regression was used to produce the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of the optic neuropathies between groups.</p><p><strong>Results: </strong>There were 11,717 and 8,676 glaucoma episodes found in the AS and no-AS groups, and there were 566 and 391 ischemic optic neuropathy episodes found in the AS and no-AS groups. The AS group had a significantly higher risk of glaucoma (aHR=1.277, 95% CI=1.242-1.312, <i>p</i><0.001) and ischemic optic neuropathy (aHR=1.362, 95% CI=1.197-1.549, <i>p</i><0.001) compared to the non-AS population. The cumulative probability of glaucoma and ischemic optic neuropathy were significantly higher in the AS group than the non-AS group (both <i>p</i><0.001). In the multivariate analysis, the incidence of ischemic optic neuropathy was significantly higher in the AS group compared to that of the non-AS group with different characteristics except in those with Asian race, aged 20-44 years old, and aged 65-80 years old (all 95% CIs included 1).</p><p><strong>Conclusion: </strong>The existence of AS correlates to higher risk of developing glaucoma and ischemic optic neuropathy.</p>\",\"PeriodicalId\":13364,\"journal\":{\"name\":\"In vivo\",\"volume\":\"39 4\",\"pages\":\"2133-2143\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223618/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"In vivo\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/invivo.14009\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"In vivo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/invivo.14009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The Correlation Between Aortic Stenosis and the Subsequent Incidence of Optic Neuropathy: A Population-based Cohort Study.
Background/aim: To survey the potential correlation between aortic stenosis (AS) and subsequent optic neuropathies of glaucoma and ischemic optic neuropathy.
Patients and methods: A retrospective cohort study was conducted with the use of the TriNetX database, a project by the US Collaborative Network which enrolled 68 healthcare institutions. PSM There were 426,980 and 426,980 people divided into the AS and non-AS groups after exclusion. The primary outcomes were the development of glaucoma and ischemic optic neuropathy. Cox proportional hazard regression was used to produce the adjusted hazard ratio (aHR) and 95% confidence interval (CI) of the optic neuropathies between groups.
Results: There were 11,717 and 8,676 glaucoma episodes found in the AS and no-AS groups, and there were 566 and 391 ischemic optic neuropathy episodes found in the AS and no-AS groups. The AS group had a significantly higher risk of glaucoma (aHR=1.277, 95% CI=1.242-1.312, p<0.001) and ischemic optic neuropathy (aHR=1.362, 95% CI=1.197-1.549, p<0.001) compared to the non-AS population. The cumulative probability of glaucoma and ischemic optic neuropathy were significantly higher in the AS group than the non-AS group (both p<0.001). In the multivariate analysis, the incidence of ischemic optic neuropathy was significantly higher in the AS group compared to that of the non-AS group with different characteristics except in those with Asian race, aged 20-44 years old, and aged 65-80 years old (all 95% CIs included 1).
Conclusion: The existence of AS correlates to higher risk of developing glaucoma and ischemic optic neuropathy.
期刊介绍：
IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management.
The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
