中国引起泌尿生殖道感染和侵袭性脑膜炎球菌病的脑膜炎奈瑟菌的出现

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2025-06-25 DOI:10.1016/j.ijid.2025.107970

Zhenhua Liu , Jian Guo , Guihua Rao , Qiang Wang , Yue Jiang , Panpan Lv , Fang Zhao , Mingliang Chen

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引用次数: 0

摘要

脑膜炎奈瑟菌（Nm）是侵袭性脑膜炎球菌病（IMD）的原因，引起泌尿生殖和肛肠感染的报道相对较少。本研究报告了2021年和2024年在中国上海发生的3例由Nm分离株引起的男性成人尿道炎病例。系统发育分析表明，这3株分离株分别与美国（Y:ST-1466）和日本（NG:ST-11026）引起IMD的菌株亲缘关系密切。值得注意的是，本研究中的所有三株分离株都具有青霉素耐药性和非源自淋病奈瑟菌的norB-aniA基因盒，这与2015年美国尿道炎分支不同。这三种尿道炎分离株也被预测为Trumenba所覆盖。引起泌尿生殖系统感染的Nm菌株已在中国出现。

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Emergence of Neisseria meningitidis causing both urogenital infection and invasive meningococcal disease in China

Neisseria meningitidis (Nm) is responsible for invasive meningococcal disease (IMD), with relatively few reports of causing urogenital and anorectal infections. This study reported the emergence of three urethritis cases in male adults caused by Nm isolates during 2021 and 2024 in Shanghai, China. Phylogenetic analysis revealed that the three isolates were closely related with strains causing IMD in the US (Y:ST-1466) and Japan (NG:ST-11026), respectively. Notably, all three isolates in this study harbored penicillin resistance and the norB-aniA gene cassette originating not from N. gonorrhoeae, which differed from the US urethritis clade in 2015. These three urethritis isolates were also predicted to be covered by Trumenba. Nm strains causing urogenital infections have emerged in China.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.