An efficient one pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)thiazol-4-yl)quinolin-2(1H)-ones

Synthesis of multiheterocyclic compounds enhances the bioactivity of core moieties. The number of heteroatoms present in the molecule provides good binding nature as well as lyophilic nature. New and efficient method has been developed for one-pot synthesis of 6-(benzyloxy)-5-(2-(2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)hydrazinyl)-thiazol-4-yl)quinolin-2(1H)-one derivatives. The reaction between 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde and thiosemicarbazide followed by cyclocondensation reaction with 6-benzyloxy-5-(2-bromo-acetyl)-1H-quinolin-2-one in ethanol under microwave or ultra-sonication condition affords the desired compounds. The described method of synthesis is time saving and contains efficient protocols.