Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle.

The problem of ulcerative colitis (UC) is becoming increasingly relevant due to its prevalence and combination with psychological disorders. UC is associated with alterations in the intestinal microbiocenosis as one of the factors reducing tolerance to self-antigens. In addition, patients with UC often experience anxiety, depression and other negative emotional and psychological factors aggravating the course of the underlying disease. The study presented by Wang et al shows that the traditional Chinese medicine Wuling can exert its therapeutic effect by reversing the aberrant precursor of brain-derived neurotrophic factor (BDNF)/ BDNF signaling in mice with UC and depression. The combination of Wuling powder with mesalazine can exhibit an antidepressant effect and reduce intestinal inflammation. Undoubtedly, the study by Chinese authors deserves attention, and changes in the balance of precursor of BDNF/p75 neurotrophin receptor/sortilin and BDNF/tropomyosin receptor kinase B signaling may become a novel therapeutic target for clinical treatment and further development of research.