血小板激活淋巴管生成作为治疗肝硬化和门静脉高压症的新途径。

IF 5.4 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Jian-Fu Li, Qing-Bo Wang, Yu-Kai Li, Yu-Bo Liang, Xing-Ming Chen, Qi-Yu Lu, Yang Ke
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引用次数: 0

摘要

这封信评论了最近发表在《世界胃肠病学杂志》上的一篇文章,在这篇文章中,作者通过采用胆管结扎(BDL)引起的肝硬化大鼠模型,证明了淋巴管生成与血小板粘附、聚集和激活过程之间的紧密联系。作者通过富血小板血浆和血管内皮生长因子3受体抑制剂MAZ-51分别激活和抑制BDL大鼠模型中的血管生成信号,采用功能获得和功能丧失两种方法来验证淋巴管生成在肝硬化和门脉高压(PHT)发展中的关键功能。在临床实践中,血小板输注已被用于改善慢性肝病和肝硬化患者的肝功能。因此,本研究为血小板输注或淋巴管生成的药物干预作为肝硬化和PHT的新治疗方法提供了支持。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Activation of lymphangiogenesis by platelet as novel therapeutic approaches for liver cirrhosis and portal hypertension.

This letter comments on the recently published article in the World Journal of Gastroenterology, in which the authors demonstrated a strong link between lymphangiogenesis and the process of platelet adherence, aggregation, and activation by employing a rat model of liver cirrhosis caused by bile duct ligation (BDL). The authors applied both gain and loss of function approach by using platelet-rich plasma and vascular endothelial growth factor 3 receptor inhibitor MAZ-51 to activate and inhibit angiogenetic signaling in BDL rat model, respectively, to verify the crucial function of lymphangiogenesis in the development of liver cirrhosis and portal hypertension (PHT). In clinical practice, platelet transfusion has been applied to improve liver function in patients suffering from chronic liver disease and cirrhosis. Therefore, this study provides support for the application of platelet transfusion or pharmacological intervention of lymphangiogenesis as novel therapeutic approaches for liver cirrhosis and PHT.

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来源期刊
World Journal of Gastroenterology
World Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
7.80
自引率
4.70%
发文量
464
审稿时长
2.4 months
期刊介绍: The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.
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