体重指数与COVID-19:意大利多中心队列卫生工作者在疫苗接种前和接种后时代- orchestra项目中的概述

IF 5.2 3区 医学 Q1 IMMUNOLOGY
Vaccines Pub Date : 2025-06-19 DOI:10.3390/vaccines13060660
Gianluca Spiteri, Lorena Torroni, Maria Grazia Lourdes Monaco, Angela Carta, Francesco Taus, Alberto Modenese, Loretta Casolari, Maria Luisa Scapellato, Filippo Liviero, Francesca Larese Filon, Francesca Rui, Giuseppe Verlato, Stefano Porru
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引用次数: 0

摘要

世界范围内的肥胖患病率正在上升,导致了全球卫生紧急情况。肥胖对SARS-CoV-2感染风险和症状严重程度的影响,特别是在卫生工作者等高危工作人群中,值得进一步研究。方法对隶属于ORCHESTRA项目的四所意大利大学医院的卫生工作者进行多中心回顾性队列研究。数据通过在线调查收集,调查社会人口和临床数据,直到2022年9月。结果共有5777名卫生工作者填写了问卷。中位年龄为46岁(I-III四分位数为20-72岁),75.5%为女性。5470名参与者的BMI数据可用。超重和肥胖分别占23.4%和9.8%。Naïve卫生工作者占多数(57.4%)。与正常体重者相比,超重和肥胖受试者仅在接种疫苗前感染的风险更高(RRR分别为1.28 (IC 95% 1.01-1.62, p = 0.039)和1.36 (IC 95% 1.00-1.86, p = 0.047)。与体重正常的受试者相比,肥胖受试者的COVID-19严重急性和急性后症状更常见(35.2%对23.5%,14.2%对9.3%)。接种疫苗后,BMI并没有降低抗体水平。相反,超重和肥胖的卫生工作者在第三次剂量后的RGM显著增加(分别为1.12和1.48;正常体重作为参考)。结论超重和肥胖人群感染SARS-CoV-2的风险较高。然而,即使在这些个体中,接种SARS-CoV-2疫苗也会产生高抗体反应。应优先在BMI高的受试者中接种针对SARS-CoV-2的疫苗,特别是在高度暴露的工人中,如卫生工作者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Body Mass Index and COVID-19: An Overview Among an Italian Multicentric Cohort of Healthcare Workers in the Pre- and Post-Vaccination Eras-ORCHESTRA Project.

Background The prevalence of obesity is increasing all over the world, resulting in a global health emergency. The impact of obesity on the risk of SARS-CoV-2 infection and symptom severity, especially among high-risk working populations such as health workers, deserves further studies. Methods A multicentric retrospective cohort study was conducted among health workers at four Italian University Hospitals belonging to the ORCHESTRA Project. Data were collected through an online survey, investigating sociodemographic and clinical data, until September 2022. Results The questionnaire was filled out by 5777 health workers. The median age was 46 years old (I-III quartile 20-72) and 75.5% were females. Data on BMI was available for 5470 participants. Overweight and obese subjects amounted to 23.4% and 9.8%, respectively. Naïve health workers were the majority (57.4%). Overweight and obese subjects were at a higher risk of infection only before vaccination with respect to normoweight subjects (RRR = 1.28 (IC 95% 1.01-1.62, p = 0.039) and 1.36 (1.00-1.86, p = 0.047), respectively). Major acute and post-acute COVID-19 symptoms were more common among obese subjects, as compared to those with a normal weight (35.2% vs. 23.5%, and 14.2% vs. 9.3%). BMI did not reduce antibody levels after vaccination. On the contrary, overweight and obese health workers had a significantly higher RGM after the third dose (1.12 and 1.48, respectively; normal weight as reference). Conclusions Overweight and obese subjects are at a higher risk of SARS-CoV-2 infection. However, SARS-CoV-2 vaccination fosters a high antibody response even in these individuals. Vaccination against SARS-CoV-2 should be prioritized in subjects with a high BMI, especially in highly exposed workers, such as health workers.

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来源期刊
Vaccines
Vaccines Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
8.90
自引率
16.70%
发文量
1853
审稿时长
18.06 days
期刊介绍: Vaccines (ISSN 2076-393X) is an international, peer-reviewed open access journal focused on laboratory and clinical vaccine research, utilization and immunization. Vaccines publishes high quality reviews, regular research papers, communications and case reports.
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