E3泛素连接酶的破坏赋予疾病抗性。

IF 17.3 1区生物学 Q1 PLANT SCIENCES

Trends in Plant Science Pub Date : 2025-06-25 DOI:10.1016/j.tplants.2025.06.007

Xiaoman You, Jisong Wang, Guo-Liang Wang, Yuese Ning

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引用次数: 0

摘要

黄龙病（HLB）是柑橘的一种毁灭性病害。在最近的一项研究中，Zhao等人发现CLas效应物SDE5靶向易感性(S)因子E3泛素连接酶PUB21，该因子降解MYC2以抑制HLB耐药性。显性负突变体PUB21DN和人工智能（AI）设计的抗蛋白水解肽（APPs）阻断PUB21，稳定MYC2并赋予HLB抗性。

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Disruption of E3 ubiquitin ligase confers disease resistance.

Huanglongbing (HLB) is a devastating disease of citrus. In a recent study, Zhao et al. found that the CLas effector SDE5 targets a susceptibility (S) factor, E3 ubiquitin ligase PUB21, which degrades MYC2 to inhibit HLB resistance. The dominant negative mutant PUB21DN and artificial intelligence (AI)-designed antiproteolysis peptides (APPs) block PUB21, stabilizing MYC2 and conferring HLB resistance.

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来源期刊

Trends in Plant Science 生物-植物科学

CiteScore

31.30

自引率

2.00%

发文量

196

审稿时长

6-12 weeks

期刊介绍： Trends in Plant Science is the primary monthly review journal in plant science, encompassing a wide range from molecular biology to ecology. It offers concise and accessible reviews and opinions on fundamental plant science topics, providing quick insights into current thinking and developments in plant biology. Geared towards researchers, students, and teachers, the articles are authoritative, authored by both established leaders in the field and emerging talents.