Mohammad Hossein Salemi, Mohammad Hossein Harirchian
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引用次数: 0
摘要
目的：本系统回顾研究旨在评价TES对MS患者认知功能障碍的影响，旨在巩固现有知识并探讨其临床适用性。方法：在MEDLINE、Scopus和EMBASE中检索符合prisma标准的随机对照试验（rct）和准实验研究，评估TES对ms认知结果的影响，采用随机效应模型汇总9项研究的数据，并按刺激类型进行亚组分析。结果：meta分析显示TES对认知功能有小到中度的综合影响（标准化平均差[SMD] = 0.62, 95% CI: 0.36-0.88, p 2 = 87.82%）。亚组分析显示，tDCS改善了认知结果（SMD = 0.32, p = 0.04），而tACS的效果更大但不显著（SMD = 1.39, p = 0.16）。TES总体上是安全的，有短暂的副作用（如头皮不适）报道。结论：TES有望成为治疗多发性硬化症患者认知功能障碍的有效且安全的干预手段。虽然在不同的认知领域观察到改善，但结果的可变性强调了进一步研究以完善刺激方案的必要性。
A systematic review of the impact of transcranial electrical stimulation (TES) on cognitive dysfunction in patients with multiple sclerosis.
Aim: This systematic review study aimed to evaluate the impact of TES on cognitive dysfunction in MS patients, aiming to consolidate current knowledge and explore its clinical applicability.
Methods: A PRISMA-compliant search of MEDLINE, Scopus, and EMBASE identified randomized controlled trials (RCTs) and quasi-experimental studies assessing TES's impact on cognitive outcomes in MS. Data from nine studies were pooled using random-effects models, with subgroup analyses by stimulation type.
Results: Meta-analysis revealed a small-to-moderate pooled effect of TES on cognitive function (standardized mean difference [SMD] = 0.62, 95% CI: 0.36-0.88, p < 0.001), though substantial heterogeneity was observed (I2 = 87.82%). Subgroup analysis showed tDCS improved cognitive outcomes (SMD = 0.32, p = 0.04), while tACS demonstrated a larger but non-significant effect (SMD = 1.39, p = 0.16). TES was generally safe, with transient side effects (e.g. scalp discomfort) reported.
Conclusion: TES shows promise as an effective and safe intervention for cognitive dysfunction in MS patients. While improvements were observed in various cognitive domains, outcome variability underscores the need for further research to refine stimulation protocols.
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