Johanna M Hoppe, Johannes Björkstrand, Johan Vegelius, Lisa Klevebrant, Malin Gingnell, Andreas Frick
{"title":"150毫克咖啡因对恐慌症患者和健康对照者焦虑的主观、生理和行为成分的急性影响——一项随机安慰剂对照交叉试验","authors":"Johanna M Hoppe, Johannes Björkstrand, Johan Vegelius, Lisa Klevebrant, Malin Gingnell, Andreas Frick","doi":"10.1177/02698811251344692","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Caffeine in doses above 400 mg, approximately four cups of coffee, induces panic attacks in 50% of individuals with panic disorder (PD) and elevates anxiety, but it is not known how individuals with PD respond to normally consumed doses or how caffeine interacts with emotional tasks.</p><p><strong>Aims: </strong>We hypothesized that 150 mg caffeine would increase subjective anxiety (primary outcome) as well as interoceptive attention and anxiety from bodily signals in patients with PD, and more so than in healthy controls (HCs). Additional analyses targeted panic attacks, emotional reactivity, avoidance behavior, and subjective exteroceptive attention.</p><p><strong>Methods: </strong>Twenty-nine patients with PD and 53 HC with low habitual caffeine consumption (⩽300 mg/week) abstained from caffeine 36 h before receiving 150 mg caffeine or placebo in a double-blind randomized crossover design 2-14 days apart.</p><p><strong>Results: </strong>Contrary to our hypotheses, caffeine did not increase subjective anxiety, interoceptive attention, or anxiety from interoceptive signals. Only one panic attack was noted, in the PD group after caffeine intake during the emotional reactivity task. In both PD and HC, caffeine increased skin conductance responses to neutral and emotional faces, augmented costly avoidance behavior, and impaired exteroceptive attention. These results indicate that low caffeine doses do not have differential anxiogenic effects in patients with PD and HC at rest, and that they increase arousal and avoidance behavior in both PD and healthy individuals.</p><p><strong>Conclusions: </strong>In conclusion, we suggest that recommendations for caffeine abstinence for patients with PD should be based on higher doses and ideally on individual assessments.</p>","PeriodicalId":16892,"journal":{"name":"Journal of Psychopharmacology","volume":" ","pages":"836-846"},"PeriodicalIF":5.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287556/pdf/","citationCount":"0","resultStr":"{\"title\":\"Acute effects of 150 mg caffeine on subjective, physiological, and behavioral components of anxiety in panic disorder and healthy controls - A randomized placebo-controlled crossover trial.\",\"authors\":\"Johanna M Hoppe, Johannes Björkstrand, Johan Vegelius, Lisa Klevebrant, Malin Gingnell, Andreas Frick\",\"doi\":\"10.1177/02698811251344692\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Caffeine in doses above 400 mg, approximately four cups of coffee, induces panic attacks in 50% of individuals with panic disorder (PD) and elevates anxiety, but it is not known how individuals with PD respond to normally consumed doses or how caffeine interacts with emotional tasks.</p><p><strong>Aims: </strong>We hypothesized that 150 mg caffeine would increase subjective anxiety (primary outcome) as well as interoceptive attention and anxiety from bodily signals in patients with PD, and more so than in healthy controls (HCs). Additional analyses targeted panic attacks, emotional reactivity, avoidance behavior, and subjective exteroceptive attention.</p><p><strong>Methods: </strong>Twenty-nine patients with PD and 53 HC with low habitual caffeine consumption (⩽300 mg/week) abstained from caffeine 36 h before receiving 150 mg caffeine or placebo in a double-blind randomized crossover design 2-14 days apart.</p><p><strong>Results: </strong>Contrary to our hypotheses, caffeine did not increase subjective anxiety, interoceptive attention, or anxiety from interoceptive signals. Only one panic attack was noted, in the PD group after caffeine intake during the emotional reactivity task. In both PD and HC, caffeine increased skin conductance responses to neutral and emotional faces, augmented costly avoidance behavior, and impaired exteroceptive attention. These results indicate that low caffeine doses do not have differential anxiogenic effects in patients with PD and HC at rest, and that they increase arousal and avoidance behavior in both PD and healthy individuals.</p><p><strong>Conclusions: </strong>In conclusion, we suggest that recommendations for caffeine abstinence for patients with PD should be based on higher doses and ideally on individual assessments.</p>\",\"PeriodicalId\":16892,\"journal\":{\"name\":\"Journal of Psychopharmacology\",\"volume\":\" \",\"pages\":\"836-846\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287556/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02698811251344692\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02698811251344692","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/27 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Acute effects of 150 mg caffeine on subjective, physiological, and behavioral components of anxiety in panic disorder and healthy controls - A randomized placebo-controlled crossover trial.
Background: Caffeine in doses above 400 mg, approximately four cups of coffee, induces panic attacks in 50% of individuals with panic disorder (PD) and elevates anxiety, but it is not known how individuals with PD respond to normally consumed doses or how caffeine interacts with emotional tasks.
Aims: We hypothesized that 150 mg caffeine would increase subjective anxiety (primary outcome) as well as interoceptive attention and anxiety from bodily signals in patients with PD, and more so than in healthy controls (HCs). Additional analyses targeted panic attacks, emotional reactivity, avoidance behavior, and subjective exteroceptive attention.
Methods: Twenty-nine patients with PD and 53 HC with low habitual caffeine consumption (⩽300 mg/week) abstained from caffeine 36 h before receiving 150 mg caffeine or placebo in a double-blind randomized crossover design 2-14 days apart.
Results: Contrary to our hypotheses, caffeine did not increase subjective anxiety, interoceptive attention, or anxiety from interoceptive signals. Only one panic attack was noted, in the PD group after caffeine intake during the emotional reactivity task. In both PD and HC, caffeine increased skin conductance responses to neutral and emotional faces, augmented costly avoidance behavior, and impaired exteroceptive attention. These results indicate that low caffeine doses do not have differential anxiogenic effects in patients with PD and HC at rest, and that they increase arousal and avoidance behavior in both PD and healthy individuals.
Conclusions: In conclusion, we suggest that recommendations for caffeine abstinence for patients with PD should be based on higher doses and ideally on individual assessments.
期刊介绍:
The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.