Heidi Espedal, Shipra Verma, Ambuj Roy, Nick S R Lan, Sheeraz Mohd, Benjamin Bartlett, Kamar Ali, Natalie C Ward, Martin A Ebert, Dick C Chan, Gerald F Watts, Girish Dwivedi, Roslyn J Francis
{"title":"氟脱氧葡萄糖正电子发射断层扫描检测症状性COVID-19后持续动脉炎症。","authors":"Heidi Espedal, Shipra Verma, Ambuj Roy, Nick S R Lan, Sheeraz Mohd, Benjamin Bartlett, Kamar Ali, Natalie C Ward, Martin A Ebert, Dick C Chan, Gerald F Watts, Girish Dwivedi, Roslyn J Francis","doi":"10.1016/j.hlc.2025.03.005","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is limited knowledge of persisting vascular and systemic inflammation in adults recovered from COVID-19. This study aimed to assess whether inflammation from symptomatic mild-to-moderate COVID-19 persists beyond the apparent clinical resolution of disease using fluorodeoxyglucose positron emission tomography (FDG-PET).</p><p><strong>Method: </strong>This observational single-centre cohort study invited adults (aged >40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19-naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.</p><p><strong>Results: </strong>FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75-113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]<sub>max</sub> 3.1; IQR 2.7-3.3) compared with the high-risk participants with CVD (median SUV<sub>max</sub> 2.5; IQR 2.2-2.8; p<0.001). There was a moderate positive correlation between the total thoracic SUV<sub>max</sub> and the bone marrow SUV<sub>mean</sub> (Spearman r=0.58; p<0.001) and the spleen mean SUV<sub>max</sub> (Spearman r=0.62, p<0.001) for participants who recovered from COVID-19.</p><p><strong>Conclusions: </strong>Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.</p>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fluorodeoxyglucose Positron Emission Tomography Detects Persistent Arterial Inflammation After Symptomatic COVID-19.\",\"authors\":\"Heidi Espedal, Shipra Verma, Ambuj Roy, Nick S R Lan, Sheeraz Mohd, Benjamin Bartlett, Kamar Ali, Natalie C Ward, Martin A Ebert, Dick C Chan, Gerald F Watts, Girish Dwivedi, Roslyn J Francis\",\"doi\":\"10.1016/j.hlc.2025.03.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is limited knowledge of persisting vascular and systemic inflammation in adults recovered from COVID-19. This study aimed to assess whether inflammation from symptomatic mild-to-moderate COVID-19 persists beyond the apparent clinical resolution of disease using fluorodeoxyglucose positron emission tomography (FDG-PET).</p><p><strong>Method: </strong>This observational single-centre cohort study invited adults (aged >40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19-naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.</p><p><strong>Results: </strong>FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75-113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]<sub>max</sub> 3.1; IQR 2.7-3.3) compared with the high-risk participants with CVD (median SUV<sub>max</sub> 2.5; IQR 2.2-2.8; p<0.001). There was a moderate positive correlation between the total thoracic SUV<sub>max</sub> and the bone marrow SUV<sub>mean</sub> (Spearman r=0.58; p<0.001) and the spleen mean SUV<sub>max</sub> (Spearman r=0.62, p<0.001) for participants who recovered from COVID-19.</p><p><strong>Conclusions: </strong>Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.</p>\",\"PeriodicalId\":13000,\"journal\":{\"name\":\"Heart, Lung and Circulation\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Heart, Lung and Circulation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.hlc.2025.03.005\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart, Lung and Circulation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.hlc.2025.03.005","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Background: There is limited knowledge of persisting vascular and systemic inflammation in adults recovered from COVID-19. This study aimed to assess whether inflammation from symptomatic mild-to-moderate COVID-19 persists beyond the apparent clinical resolution of disease using fluorodeoxyglucose positron emission tomography (FDG-PET).
Method: This observational single-centre cohort study invited adults (aged >40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19-naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.
Results: FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75-113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]max 3.1; IQR 2.7-3.3) compared with the high-risk participants with CVD (median SUVmax 2.5; IQR 2.2-2.8; p<0.001). There was a moderate positive correlation between the total thoracic SUVmax and the bone marrow SUVmean (Spearman r=0.58; p<0.001) and the spleen mean SUVmax (Spearman r=0.62, p<0.001) for participants who recovered from COVID-19.
Conclusions: Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.
期刊介绍:
Heart, Lung and Circulation publishes articles integrating clinical and research activities in the fields of basic cardiovascular science, clinical cardiology and cardiac surgery, with a focus on emerging issues in cardiovascular disease. The journal promotes multidisciplinary dialogue between cardiologists, cardiothoracic surgeons, cardio-pulmonary physicians and cardiovascular scientists.