肠道微生物组改变中代谢组学研究的问题与展望。

Q3 Biochemistry, Genetics and Molecular Biology
E I Savelieva, M D Shachneva
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引用次数: 0

摘要

本文综述了关于某些疾病与肠道微生物群改变(变性)之间关系的现有知识。我们认为主要的微生物代谢物被认为是在微生物组和宿主生物之间的通讯中起作用的信号分子。这些包括短链脂肪酸、胆汁酸、胺、氨基酸及其代谢物。特别关注慢性肾脏疾病,特别是免疫球蛋白A肾病中微生物组的代谢组学研究。支持血液微生物群概念的论据,以前被认为是健康人的完全无菌环境。宏基因组学方法在微生物群落组成和潜在生理效应的表征中起着关键作用。分析了血清/血浆和粪便代谢组学分析的优点和局限性。由于微生物组-代谢组相互影响的临床研究潜力受到遗传和外部因素的限制,临床前研究仍然采用无细菌模型和基于抗生素作用的模型。综述了代谢组学在研究微生物组和代谢组相互影响的性质和机制方面存在的问题和前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Problems and prospects of metabolomic studies in the alteration of the gut microbiome.

The review summarizes existing knowledge on the relationship between certain diseases and alteration (degeneration) of the intestinal microbiome. We consider major microbial metabolites firmly recognized as signaling molecules acting in communication between the microbiome and the host organism. These include short-chain fatty acids, bile acids, amines, amino acids, and their metabolites. Special attention is paid to metabolomic studies of the microbiome in chronic kidney diseases, in particular, immunoglobulin A nephropathy. The arguments supporting a concept of the microbiome of blood, previously considered an exclusively sterile environment in healthy humans, are considered. Metagenomic methods plays a key role in characterization of both the composition and potential physiological effects of microbial communities. The advantages and limitations of metabolomic analysis of blood serum/plasma and feces have been analyzed. Since the potential of clinical studies of the mutual impact of the microbiome-metabolome is limited by genetic and external factors, preclinical studies still employ both germ-free models and models based on the effects of antibiotics. The review considers the problems and prospects of metabolomics in studying the nature and mechanisms of the mutual impact of the microbiome and metabolome.

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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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