{"title":"雌性山羊性成熟过程中下丘脑环状rna特征分析及关键环状rna鉴定。","authors":"Qing Li, Jian-Min Wang, Yanyan Wang, Peipei He, Lu Zhang, Tianle Chao","doi":"10.5713/ab.25.0275","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Precocious puberty can shorten reproductive cycles, enhance reproductive capacity, and reduce feeding costs. Consequently, precocious livestock are widely utilized in cross-breeding. This study aims to elucidate the key molecular mechanisms by which circular RNA (circRNA) regulates the sexual maturation of sexually precocious goats.</p><p><strong>Methods: </strong>In this study, we analyzed the circRNA expression profiles of hypothalamic tissue from Jining grey goats at four distinct postnatal developmental stages (1 day, 2 months, 4 months, 6 months).</p><p><strong>Results: </strong>A total of 23,993 circRNAs were identified across these stages, predominantly derived from exonic regions, with 1,052 circRNAs exhibiting differential expression. Additionally, competitive endogenous RNA (ceRNA) analysis suggested that novel_circ_0002274/chi-miR-197-5p/ estrogen receptor 1 (ESR1) and novel_circ_0002274/chi-miR-30c-3p/ oxytocin/neurophysin I prepropeptide (OXT) may regulate sexual maturation in goats via the estrogen signaling pathway and the oxytocin signaling pathway.</p><p><strong>Conclusion: </strong>This study contributes to understanding the function of circRNAs in hypothalamic regulation of sexual maturation and provides valuable insights for breeding superior goat breeds.</p>","PeriodicalId":7825,"journal":{"name":"Animal Bioscience","volume":" ","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of circRNA characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats.\",\"authors\":\"Qing Li, Jian-Min Wang, Yanyan Wang, Peipei He, Lu Zhang, Tianle Chao\",\"doi\":\"10.5713/ab.25.0275\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Precocious puberty can shorten reproductive cycles, enhance reproductive capacity, and reduce feeding costs. Consequently, precocious livestock are widely utilized in cross-breeding. This study aims to elucidate the key molecular mechanisms by which circular RNA (circRNA) regulates the sexual maturation of sexually precocious goats.</p><p><strong>Methods: </strong>In this study, we analyzed the circRNA expression profiles of hypothalamic tissue from Jining grey goats at four distinct postnatal developmental stages (1 day, 2 months, 4 months, 6 months).</p><p><strong>Results: </strong>A total of 23,993 circRNAs were identified across these stages, predominantly derived from exonic regions, with 1,052 circRNAs exhibiting differential expression. Additionally, competitive endogenous RNA (ceRNA) analysis suggested that novel_circ_0002274/chi-miR-197-5p/ estrogen receptor 1 (ESR1) and novel_circ_0002274/chi-miR-30c-3p/ oxytocin/neurophysin I prepropeptide (OXT) may regulate sexual maturation in goats via the estrogen signaling pathway and the oxytocin signaling pathway.</p><p><strong>Conclusion: </strong>This study contributes to understanding the function of circRNAs in hypothalamic regulation of sexual maturation and provides valuable insights for breeding superior goat breeds.</p>\",\"PeriodicalId\":7825,\"journal\":{\"name\":\"Animal Bioscience\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Animal Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.5713/ab.25.0275\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Animal Bioscience","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.5713/ab.25.0275","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0
摘要
目的：性早熟可缩短生殖周期，增强生殖能力，降低饲养成本。因此，早熟家畜在杂交育种中得到了广泛的应用。本研究旨在阐明环状RNA （circRNA）调控性早熟山羊性成熟的关键分子机制。方法：在本研究中，我们分析了吉宁灰山羊在出生后4个不同发育阶段（1天、2个月、4个月、6个月）下丘脑组织的circRNA表达谱。结果：在这些阶段共鉴定出23,993个circrna，主要来自外显子区域，其中1,052个circrna表现出差异表达。此外，竞争性内源性RNA （ceRNA）分析表明，novel_circ_0002274/chi- mir - 197,5p /雌激素受体1 （ESR1）和novel_circ_0002274/chi-miR-30c-3p/催产素/神经physin I前肽（OXT）可能通过雌激素信号通路和催产素信号通路调节山羊性成熟。结论：本研究有助于了解circRNAs在下丘脑性成熟调控中的功能，为培育优良山羊品种提供有价值的见解。
Analysis of circRNA characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats.
Objective: Precocious puberty can shorten reproductive cycles, enhance reproductive capacity, and reduce feeding costs. Consequently, precocious livestock are widely utilized in cross-breeding. This study aims to elucidate the key molecular mechanisms by which circular RNA (circRNA) regulates the sexual maturation of sexually precocious goats.
Methods: In this study, we analyzed the circRNA expression profiles of hypothalamic tissue from Jining grey goats at four distinct postnatal developmental stages (1 day, 2 months, 4 months, 6 months).
Results: A total of 23,993 circRNAs were identified across these stages, predominantly derived from exonic regions, with 1,052 circRNAs exhibiting differential expression. Additionally, competitive endogenous RNA (ceRNA) analysis suggested that novel_circ_0002274/chi-miR-197-5p/ estrogen receptor 1 (ESR1) and novel_circ_0002274/chi-miR-30c-3p/ oxytocin/neurophysin I prepropeptide (OXT) may regulate sexual maturation in goats via the estrogen signaling pathway and the oxytocin signaling pathway.
Conclusion: This study contributes to understanding the function of circRNAs in hypothalamic regulation of sexual maturation and provides valuable insights for breeding superior goat breeds.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
