含有果硼酸钙负载的介孔二氧化硅纳米颗粒的树脂基纸浆封盖材料的理化、细胞毒性和抗菌性能的研究。

IF 6.3 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Dental Materials Pub Date : 2025-06-25 DOI:10.1016/j.dental.2025.06.019

Hacer Balkaya , Sezer Demirbuğa , Serkan Dayan , Nilay Ildız , Hatice Bekci

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引用次数: 0

摘要

目的：本研究旨在评估一种含有负载果糖硼酸钙介孔二氧化硅（SBA-15）的树脂基牙髓封盖材料的物理化学、细胞毒性和抗菌性能。方法：将果硼酸钙负载于介孔二氧化硅中，分别以3 %和5 %的质量浓度掺入树脂基盖髓材料中。研究组的定义如下：不含含果糖硼酸钙SBA-15的组（对照组），含3 %果糖硼酸钙SBA-15的组（%3 CF@SBA-15），含5 %果糖硼酸钙SBA-15的组（%5 CF@SBA-15）。然后测试了所得到的实验盖层材料的吸水性、溶解度、单体转化率、抗菌活性、细胞毒性和干细胞分化。结果：CF@SBA-15的加入显著降低了材料的吸水率（p  0.05）。随着材料中CF@SBA-15浓度的增加，对变形链球菌和干酪乳杆菌的抗菌活性均显著提高（p ）。意义：CF@SBA-15的掺入显著增强了树脂基盖髓材料的生物相容性和抗菌性能。此外，CF@SBA-15对干细胞分化的影响及其在这些材料中支持硬组织形成的潜力显示出有希望的结果。

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Investigation of the physicochemical, cytotoxic, and antimicrobial properties of a resin-based pulp capping material incorporated with calcium fructoborate-loaded mesoporous silica nanoparticles

Objectives

This study aims to evaluate the physicochemical, cytotoxic, and antimicrobial properties of a resin-based pulp capping material incorporating calcium fructoborate-loaded mesoporous silica (SBA-15).

Methods

In the study, calcium fructoborate was loaded into mesoporous silica and then incorporated into the resin-based pulp capping material at concentrations of 3 % and 5 % by weight. The study groups were defined as follows: the group without calcium fructoborate-loaded SBA-15 (Control), the group containing 3 % calcium fructoborate-loaded SBA-15 (%3 CF@SBA-15), and the group containing 5 % calcium fructoborate-loaded SBA-15 (%5 CF@SBA-15). The resulting experimental capping materials were then tested for water absorption, solubility, monomer conversion, antibacterial activity, cytotoxicity, and stem cell differentiation.

Results

The addition of CF@SBA-15 significantly reduced the material’s water absorption (p < 0.05), while no statistically significant difference was observed between the groups in terms of solubility and monomer conversion (p > 0.05). As the CF@SBA-15 concentration in the material increased, the antibacterial activity against both S. mutans and L. casei significantly improved (p < 0.05). The addition of 3 % and 5 % CF@SBA-15 significantly increased the biocompatibility (p < 0.05). The 5 % CF@SBA-15 group exhibited statistically significantly the highest stem cell differentiation potential, followed by the 3 % CF@SBA-15 group and the control group (p < 0.05). When compared to the control medium, the differentiation level in the CF@SBA-15-containing groups was higher (p < 0.05).

Significance

The incorporation of CF@SBA-15 significantly enhanced the biocompatibility and antibacterial properties of the resin-based pulp capping materials. Furthermore, the influence of CF@SBA-15 on stem cell differentiation and its potential to support hard tissue formation in these materials shows promising results.

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来源期刊

Dental Materials 工程技术-材料科学：生物材料

CiteScore

9.80

自引率

10.00%

发文量

290

审稿时长

67 days

期刊介绍： Dental Materials publishes original research, review articles, and short communications. Academy of Dental Materials members click here to register for free access to Dental Materials online. The principal aim of Dental Materials is to promote rapid communication of scientific information between academia, industry, and the dental practitioner. Original Manuscripts on clinical and laboratory research of basic and applied character which focus on the properties or performance of dental materials or the reaction of host tissues to materials are given priority publication. Other acceptable topics include application technology in clinical dentistry and dental laboratory technology. Comprehensive reviews and editorial commentaries on pertinent subjects will be considered.