揭示登革热和寨卡病毒蛋白-宿主膜相互作用

IF 3.2 3区生物学 Q2 BIOPHYSICS

Biophysical journal Pub Date : 2025-06-25 DOI:10.1016/j.bpj.2025.06.032

Natalia Philipp, Guadalupe S. Costa Navarro, Luana de Borba, Andrea V. Gamarnik, Laura C. Estrada

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引用次数: 0

摘要

蚊媒黄病毒，包括登革热病毒（DENV）和寨卡病毒（ZIKV），构成重大和不断升级的公共卫生威胁。阐明这些黄病毒通过病毒蛋白-宿主细胞相互作用破坏细胞过程的机制，为了解它们的复制和致病性提供了重要的见解。在这里，我们提出了一个基于光栅图像中像素各向异性计算的分析，以研究核细胞质穿梭过程中的差异蛋白质相互作用。这种方法突出了高各向异性和低各向异性的区域，表明不同的蛋白质-膜相互作用。

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Unraveling viral protein-host membrane interaction for dengue and Zika

Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), constitute a significant and escalating public health threat. Elucidating the mechanisms by which these flaviviruses subvert cellular processes through viral protein-host cell interactions provides critical insights into their replication and pathogenicity. Here, we present an analysis based on anisotropy calculation across pixels in raster images to investigate differential protein interactions during nucleocytoplasmic shuttling. This methodology highlights regions of high and low anisotropy, suggesting differential protein-membrane interactions.

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来源期刊

Biophysical journal 生物-生物物理

CiteScore

6.10

自引率

5.90%

发文量

3090

审稿时长

2 months

期刊介绍： BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.