Elizabeth M. Leach, David K. Powell, Amanda C. Glueck, Elizabeth Head, Moaz W. Ibrahim, Amelia J. Anderson-Mooney, Kathryn L. Van Pelt, Jordan P. Harp, Frederick A. Schmitt, Ahmed A. Bahrani
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This longitudinal parent substudy aimed to explore relationships between gait, white matter (WM) integrity, and cognitive function in DS.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>The associations were investigated between magnetic resonance imaging diffusion tensor imaging (DTI), cognition, and self-paced gait data from 22 DS participants (mean age ± SD 37 ± 7.5 years).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>DTI measures, such as lower fractional anisotropy (FA) and higher mean diffusivity, were correlated with greater step time variability but not normalized velocities. Lower cognitive scores on the Vineland Adaptive Behavior Composite, Dementia Questionnaire for People with Learning Disabilities, and Motor Skill subscale were correlated with FA.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Gait variability correlates with WM integrity and cognitive function in DS, suggesting that gait and DTI measures may serve as clinical markers of neurological decline.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Gait variability linked to white matter integrity in individuals with Down syndrome (DS).</li>\n \n <li>Lower fractional anisotropy and higher mean diffusivity are associated with increased step time variability in DS.</li>\n \n <li>Cognitive decline is tied to white matter changes in motor-related brain regions.</li>\n \n <li>Gait analysis alongside diffusion tensor imaging may aid in screening for cognitive impairment in DS.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 7","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70407","citationCount":"0","resultStr":"{\"title\":\"Gait variability as a marker of white matter integrity in individuals with Down syndrome\",\"authors\":\"Elizabeth M. 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Gait variability as a marker of white matter integrity in individuals with Down syndrome
INTRODUCTION
Individuals with Down syndrome (DS) face a significant risk of neurodegeneration, and gait variability may serve as a clinical biomarker of neurological health. This longitudinal parent substudy aimed to explore relationships between gait, white matter (WM) integrity, and cognitive function in DS.
METHODS
The associations were investigated between magnetic resonance imaging diffusion tensor imaging (DTI), cognition, and self-paced gait data from 22 DS participants (mean age ± SD 37 ± 7.5 years).
RESULTS
DTI measures, such as lower fractional anisotropy (FA) and higher mean diffusivity, were correlated with greater step time variability but not normalized velocities. Lower cognitive scores on the Vineland Adaptive Behavior Composite, Dementia Questionnaire for People with Learning Disabilities, and Motor Skill subscale were correlated with FA.
DISCUSSION
Gait variability correlates with WM integrity and cognitive function in DS, suggesting that gait and DTI measures may serve as clinical markers of neurological decline.
Highlights
Gait variability linked to white matter integrity in individuals with Down syndrome (DS).
Lower fractional anisotropy and higher mean diffusivity are associated with increased step time variability in DS.
Cognitive decline is tied to white matter changes in motor-related brain regions.
Gait analysis alongside diffusion tensor imaging may aid in screening for cognitive impairment in DS.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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