{"title":"PTBP1与癌症：从RNA调控到治疗潜力","authors":"Chengdong Ji, Jing Zhu, Xiaochen Hou, Chen Zhou, Jiumei Zhao, Xiang Zheng, Yu Tang","doi":"10.1111/jcmm.70675","DOIUrl":null,"url":null,"abstract":"<p>Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA-binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non-coding RNA action processes and affect tumorigenesis and progression. In tumour therapy, PTBP1 may act as a key factor influencing targeted drug targets. Therefore, in this paper, we reviewed the structure and function of PTBP1, its role in various tumours, and key mechanisms of action. Moreover, we discuss the difficulties and challenges faced in PTBP1 research and the clinical translational potential of PTBP1 research and summarise the future research direction of PTBP1 to provide new ideas for basic research and new directions for precision treatment of tumours in the clinic.</p>","PeriodicalId":101321,"journal":{"name":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","volume":"29 13","pages":""},"PeriodicalIF":5.3000,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70675","citationCount":"0","resultStr":"{\"title\":\"PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential\",\"authors\":\"Chengdong Ji, Jing Zhu, Xiaochen Hou, Chen Zhou, Jiumei Zhao, Xiang Zheng, Yu Tang\",\"doi\":\"10.1111/jcmm.70675\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA-binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non-coding RNA action processes and affect tumorigenesis and progression. In tumour therapy, PTBP1 may act as a key factor influencing targeted drug targets. Therefore, in this paper, we reviewed the structure and function of PTBP1, its role in various tumours, and key mechanisms of action. Moreover, we discuss the difficulties and challenges faced in PTBP1 research and the clinical translational potential of PTBP1 research and summarise the future research direction of PTBP1 to provide new ideas for basic research and new directions for precision treatment of tumours in the clinic.</p>\",\"PeriodicalId\":101321,\"journal\":{\"name\":\"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE\",\"volume\":\"29 13\",\"pages\":\"\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jcmm.70675\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jcmm.70675\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF CELLULAR AND MOLECULAR MEDICINE","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jcmm.70675","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential
Polypyrimidine tract binding protein 1 (PTBP1) belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and is a widely studied RNA-binding protein involved in regulating mRNA splicing, stability, localization, and translation. In addition, PTBP1 can participate in various non-coding RNA action processes and affect tumorigenesis and progression. In tumour therapy, PTBP1 may act as a key factor influencing targeted drug targets. Therefore, in this paper, we reviewed the structure and function of PTBP1, its role in various tumours, and key mechanisms of action. Moreover, we discuss the difficulties and challenges faced in PTBP1 research and the clinical translational potential of PTBP1 research and summarise the future research direction of PTBP1 to provide new ideas for basic research and new directions for precision treatment of tumours in the clinic.
期刊介绍：
The Journal of Cellular and Molecular Medicine serves as a bridge between physiology and cellular medicine, as well as molecular biology and molecular therapeutics. With a 20-year history, the journal adopts an interdisciplinary approach to showcase innovative discoveries.
It publishes research aimed at advancing the collective understanding of the cellular and molecular mechanisms underlying diseases. The journal emphasizes translational studies that translate this knowledge into therapeutic strategies. Being fully open access, the journal is accessible to all readers.
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