损失厌恶与后岛/躯体感觉皮层特征之间u型关系的形态计量学证据

IF 3.5 2区 医学 Q1 NEUROIMAGING
Maria Arioli, Letizia Richelli, Giulia Mattavelli, Zaira Cattaneo, Paolo Poggi, Nicola Canessa
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引用次数: 0

摘要

神经经济学的研究结果表明,内感受性敏感性导致了预期损失对收益的典型高估,即所谓的“损失厌恶”。然而,后者是否与脑岛的形态特征有关(脑岛是内接收的关键节点),由于之前的证据相互矛盾,它们各自的指标之间存在正相关和负相关,因此仍然存在争议。我们将完善的行为建模方法与全面的形态计量学方案相结合,在208名健康年轻人的样本中探索损失厌恶与不同的基于体素和基于表面的皮层特征之间的线性和二次关系。单变量和多变量分析都强调了损失厌恶与后脑岛和体感顶叶皮层的不同形态特征之间的正二次(即u形)关系。这些结果首先表明,之前不一致的发现可能反映了研究方法上的差异,有助于发现损失厌恶与结构特征之间u形关系的下降或上升部分。此外,他们还对选择相关评估的内感受调节提供了新的见解,这些评估指导决策朝向或远离损失规避,从而为研究神经精神疾病中这一机制的改变及其对包括神经调节在内的不同类型干预的易感性铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Morphometric Evidence of a U-Shaped Relationship Between Loss Aversion and Posterior Insular/Somatosensory Cortical Features

Morphometric Evidence of a U-Shaped Relationship Between Loss Aversion and Posterior Insular/Somatosensory Cortical Features

Neuroeconomic findings show that interoceptive sensitivity contributes to the typical overweighting of prospective losses over gains known as “loss aversion.” Whether the latter is related to the morphometric properties of the insula—a key node for interoception—remains, however, debated, due to previous conflicting evidence of both positive and negative correlations between their respective metrics. We combined a well-established behavioral modeling approach with a comprehensive morphometric protocol to explore both a linear and quadratic relationship between loss aversion and distinct voxel-based and surface-based cortical features in a sample of 208 healthy young individuals. Both univariate and multivariate analyses highlighted a positive quadratic (i.e., U-shaped) relationship between loss aversion and distinct morphometric features of the posterior insula and somatosensory-parietal cortex. These results first suggest that previous inconsistent findings might reflect methodological differences across studies, facilitating the detection of either the descending or ascending sectors of a U-shaped relationship between loss aversion and structural features. Moreover, they provide novel insights into the interoceptive modulation of choice-related evaluations guiding decision-making towards or away from loss avoidance, thus paving the way to studies investigating alterations of this mechanism in neuro-psychiatric conditions and its susceptibility to different types of intervention including neuromodulation.

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来源期刊
Human Brain Mapping
Human Brain Mapping 医学-核医学
CiteScore
8.30
自引率
6.20%
发文量
401
审稿时长
3-6 weeks
期刊介绍: Human Brain Mapping publishes peer-reviewed basic, clinical, technical, and theoretical research in the interdisciplinary and rapidly expanding field of human brain mapping. The journal features research derived from non-invasive brain imaging modalities used to explore the spatial and temporal organization of the neural systems supporting human behavior. Imaging modalities of interest include positron emission tomography, event-related potentials, electro-and magnetoencephalography, magnetic resonance imaging, and single-photon emission tomography. Brain mapping research in both normal and clinical populations is encouraged. Article formats include Research Articles, Review Articles, Clinical Case Studies, and Technique, as well as Technological Developments, Theoretical Articles, and Synthetic Reviews. Technical advances, such as novel brain imaging methods, analyses for detecting or localizing neural activity, synergistic uses of multiple imaging modalities, and strategies for the design of behavioral paradigms and neural-systems modeling are of particular interest. The journal endorses the propagation of methodological standards and encourages database development in the field of human brain mapping.
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