用于增强x射线引发的癌症治疗的纳米材料:进展与前景

BMEMat Pub Date : 2024-10-25 DOI:10.1002/bmm2.12122
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan
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引用次数: 0

摘要

x射线是一种能量高、穿透能力强的电离辐射,常用于临床肿瘤放疗治疗。尽管它们被广泛使用,但由于诸如抗辐射和对周围健康组织的损伤等问题,优化x射线疗效仍然是一个关键的挑战。纳米技术的最新进展为癌症的诊断和治疗带来了新的机遇和挑战。本文综述了纳米材料在x射线引发的癌症治疗中的最新进展,重点介绍了纳米材料在靶向递送、减少副作用、提高治疗效果等方面的优势。我们研究了包括金属、金属氧化物、金属硫化物、金属氟化物、稀土氧化物、簇状化合物、金属有机框架和纳米杂化物在内的纳米材料如何增强x射线触发治疗的有效性。此外,我们还讨论了当前的挑战和未来的前景,旨在为该领域的研究人员和临床医生提供一个全面的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects

Nanomaterials for enhanced X-ray-triggered cancer therapy: Progress and prospects

X-rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical tumor treatment through radiotherapy. Despite their widespread use, optimizing X-ray efficacy remains a critical challenge due to issues such as radiation resistance and damage to surrounding health tissues. Recent advancements in nanotechnology have introduced new opportunities and challenges in cancer diagnosis and treatment. This review summarizes the latest progress in nanomaterials for X-ray-triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. We examine how nanomaterials, including metals, metal oxides, metal sulfides, metal fluorides, rare earth oxides, cluster compounds, metal-organic frameworks, and nanohybrids, enhance the effectiveness of X-ray-triggered treatments. Furthermore, we address the current challenges and future prospects of efficient X-ray-triggered cancer therapy, aiming to provide a comprehensive overview for researchers and clinicians in the field.

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