热疗用磁性核壳纳米粒子：基于双相位滞后模型的肝组织软硬核壳磁性材料的数值研究

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-06-27 DOI:10.1016/j.bbrep.2025.102084

M. Moshtagh , M. Servatkhah , S. Hosseini , Gh Solookinejad

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引用次数: 0

摘要

本文采用基于软硬铁氧体相（Zn 0.4 co 0.6Fe 2O 4 @Zn 0.4 Mn 0.6Fe 2O 4）的核壳磁性纳米颗粒，在交流磁场的影响下进行局部热治疗，模拟肝脏组织的热量分布和肿瘤破坏。双相滞后（DPL）模型预测的最高温度低于Pennes生物热模型和单相滞后（SPL）模型。此外，利用DPL模型模拟了不同核壳纳米粒子在交流磁场下的温度随时间的分布。最高温度与Zn 0.4 Co 0.6 Fe2O4 @Zn 0.4 Mn 0.6 Fe2O4有关，最低温度与MnFe2O4有关。与MnFe2O4、MnFe2O4 @ CoFe2O4和CoFe2O4 @MnFe2O4磁性纳米颗粒相比，这些组合使磁性纳米颗粒的性能最大化，具有更高的SLP值和更大的功耗。利用DPL模型对肝脏组织温度随时间的二维分布进行模拟，定量研究不同部位肿瘤温度。结果表明，温度曲线呈类高斯分布。温度曲线绕y轴对称。肿瘤中心温度最高，呈放射状向外降低。

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Magnetic core-shell nanoparticles for Hyperthermia: A numerical study of soft and hard core-shell magnetic materials in liver tissue based on dual phase lag model

In this article, local hyperthermia using core-shell magnetic nanoparticles based on soft and hard magnetic ferrite phases, comprising Zn _0.4Co _0.6Fe ₂O ₄ @Zn _0.4 Mn _0.6 Fe ₂O ₄, under the influence of an AC magnetic field, has been numerically investigated to simulate heat distribution and tumor destruction in liver tissue.

It is observed that the dual-phase-lag (DPL) model predicts the maximum temperature lower than both the Pennes bioheat and the single-phase-lag (SPL) model. In addition simulation of temperature distribution over time considering different core-shell nanoparticles in AC magnetic field, has been performed using DPL model. The highest temperature is related to Zn _0.4 Co _0.6 Fe ₂O₄ @Zn _0.4 Mn _0.6 Fe ₂O₄ and the lowest temperature is related to MnFe₂O₄.We have concluded that these combinations maximize the properties of magnetic nanoparticles and have higher SLP values and more power dissipation of magnetic nanoparticles compared to magnetic nanoparticles of MnFe₂O ₄, MnFe₂O₄ @ CoFe₂O₄ and CoFe₂O₄ @MnFe₂O4.

Two-dimensional temperature distribution simulation over time in liver tissue has been performed using DPL model to quantitatively investigate the tumor temperature in different locations. The results show that temperature curves is a Gaussian-like distribution. The temperature curve is symmetric around the y axis. Temperature is maximum at the center of the tumor and decreases radially outward.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.