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淫羊藿萜类化合物及其对肺上皮细胞的保护作用

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-06-25 DOI:10.1016/j.phytochem.2025.114599

Ling Li , Qianqian Yin , Yanping Zhang , Linlin Yang , Yue Gao , Jinle Hao , Bin Lin , Di Zhou , Ning Li

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引用次数: 0

摘要

毛菖蒲细枝和叶中萜类化合物对肺上皮细胞有明显的保护作用。以肺上皮细胞保护活性为指导，从毛竹中分离得到19种三萜（1 - 19）、6种二萜（20 - 25）和4种倍半萜（26-29），包括4种未报道的化合物（1、16、20和22）。所有结构均经HR-ESI-MS、NMR和ECD谱证实。使用nnk诱导的MLE-12细胞评估这些化合物的肺上皮保护作用。生物实验表明，化合物1 ~ 2、4 ~ 6、8、10、12 ~ 15均能逆转NNK对MLE-12细胞的损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Terpenoids from Aglaia edulis and their lung epithelial cells protective activity

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Terpenoids from Aglaia edulis and their lung epithelial cells protective activity

A significant protective effect on lung epithelial cells was observed with the terpenoids of Aglaia edulis twigs and leaves. Lung epithelial cells protective activity guided phytochemical research afforded nineteen triterpenoids (1–19), six diterpenoids (20–25) and four sesquiterpenes (26–29), including four unreported compounds (1, 16, 20 and 22), from A. edulis. All structures were clarified by HR-ESI-MS, NMR and ECD spectra. The lung epithelial protective effect of these compounds was assessed using NNK-induced MLE-12 cells. Biological assay indicated that compounds 1–2, 4–6, 8, 10, 12–15 could reverse the damage induced by NNK in MLE-12 cells.

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来源期刊

Phytochemistry

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.

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