ZnBr2催化顺序a3偶联和分子内环化：一锅法合成3-氨基呋喃

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-06-19 DOI:10.1016/j.tetlet.2025.155718

Battini Geetha Rani , Sreedhar Gundekari , Kola Ramesh , Chandra Sekhar Vasam , Narasimha Swamy Thirukovela

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引用次数: 0

摘要

以简单的α-酮醛、仲胺和末端炔为原料合成3-氨基呋喃时，ZnBr2盐是促进多米诺a3偶联和分子内环化的有效催化剂。该方法与多种底物兼容，并且由于形成水作为副产物，操作简单，原子经济，反应时间短，催化剂便宜而具有吸引力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

ZnBr2 catalyzed sequential A3-coupling and intramolecular cyclization: One-pot synthesis of 3-aminofurans

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ZnBr2 catalyzed sequential A3-coupling and intramolecular cyclization: One-pot synthesis of 3-aminofurans

ZnBr₂ salt was observed to be an effective catalyst to promote domino A³-coupling and intramolecular cyclization for the synthesis of 3-aminofurans from simple and commercially available α-ketoaldehydes, secondary amines, and terminal alkynes as starting materials. This method is compatible with several substrates and attractive, due to the formation of water as a by-product, operational simplicity, atom-economy, shorter reaction time, and inexpensive catalyst.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.