铜催化n -丙炔- n -甲酰基肼环化：1,5-二取代吡唑的简易制备

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-06-23 DOI:10.1016/j.tetlet.2025.155721

Cheng-Cheng Wei, Yu-Mei Zhang, Yi Li, Mei-Hua Shen, Hua-Dong Xu

引用次数: 0

摘要

CuBr∙SMe2催化n -tosy- n -丙炔肼衍生物的分子内环化形成n -取代吡唑，可能是通过5-内环化和随后的消除芳构化的一锅两步多米诺骨牌反应建立的。合成了19种n取代吡唑，收率从优异到优异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper catalyzed cyclization of N-propargyl-N-tosyl hydrazines: Facile preparation of 1,5-disubstituted pyrazoles

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Copper catalyzed cyclization of N-propargyl-N-tosyl hydrazines: Facile preparation of 1,5-disubstituted pyrazoles

A CuBr∙SMe₂ catalyzed intramolecular cyclization of N-tosy-N-propargyl hydrazine derivatives to form N-substituted pyrazoles was established, presumably, through a one-pot-two-step domino of 5-endo-dig cyclization and subsequent eliminative aromatization. Nineteen N-substituted pyrazoles were made with good to excellent yields.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.