贯叶连翘油预防肝素皮下注射引起的瘀斑和疼痛：一项自我对照单盲研究

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-05-16 DOI:10.1016/j.aimed.2025.100504

Hatice Demi̇rdağ , Nurcan Uysal , Fatma Zehra Kamber

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引用次数: 0

摘要

背景：低分子量肝素是一种具有抗凝和抗血栓作用的药物。这种药经常由护士给病人皮下注射。注射部位通常会出现疼痛、瘀斑和血肿等并发症。本研究探讨贯叶连翘油对皮下注射低分子肝素后疼痛和瘀斑的预防作用。方法对160例冠心病重症监护患者进行准实验单盲研究。研究护士在注射前2 h将5-6滴贯叶连翘油滴于患者单臂。患者的另一只手臂作为对照组。总共进行了320次注射。注射部位的评估由另外两名研究人员在48小时进行。采用Wilcoxon和McNemar检验对数据进行分析。结果应用贯叶连翘油组疼痛评分平均值为0.08 ± 0.55，瘀斑大小平均值为2.49 ± 10.32 mm。对照组注射后第48 h疼痛评分平均为1.28 ± 1.97，瘀斑大小平均为13.29 ± 18.99 mm。两组测量值的差异有统计学意义（p = .000）。结论贯叶连翘油对低分子肝素注射后的疼痛和瘀斑有明显的预防作用。然而，这项研究需要重复进行。

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Effect of Hypericum perforatum oil on prevention ecchymosis and pain associated with subcutaneous heparin injection: A self-controlled single-blind study

Background

Low molecular weight heparin is a drug with anticoagulant and antithrombotic effects. This drug is frequently administered subcutaneously to patients by nurses. Complications such as pain, ecchymosis and hematoma may commonly occur at the injection site. This study investigated the effect of Hypericum perforatum oil in preventing pain and ecchymosis after subcutaneous injection low molecular weight heparin.

Methods

This quasi-experimental and single blinded study was conducted with 160 patients in a coronary intensive care unit. The researcher nurse applied 5–6 drops of Hypericum perforatum oil to one arm of the patients 2 h before the injection. The other arm of the patient was considered as the control arm. A total of 320 injections were administered. The evaluation of the injection sites was performed by two other researchers at 48th hours. The data were analyzed using Wilcoxon and McNemar test.

Results

In the arm which was applied Hypericum perforatum oil the mean pain score was 0.08 ± 0.55 and the mean ecchymosis size was 2.49 ± 10.32 mm. In the control arm, the mean pain score was 1.28 ± 1.97 and the mean ecchymosis size was 13.29 ± 18.99 mm according to the measurements made at 48th h after injection. The difference between the measurements in both arms was statistically significant (p = .000).

Conclusions

It showed that Hypericum perforatum oil is effective in preventing pain and ecchymosis after low molecular weight heparin injection. However, the research needs to be repeated.

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.