Bonnie E Gould Rothberg, Alberto J Caban-Martinez, Dana Boyd Barr, Mark A Jara, Valentina Rodriguez, Paola Louzado Feliciano, Katerina M Santiago, Cynthia Campos Beaver, Erin N Kobetz-Kerman, Natasha Schaefer Solle
{"title":"多溴联苯醚（PBDEs），职业暴露和甲状腺功能在美国和加拿大消防员：一个横断面研究。","authors":"Bonnie E Gould Rothberg, Alberto J Caban-Martinez, Dana Boyd Barr, Mark A Jara, Valentina Rodriguez, Paola Louzado Feliciano, Katerina M Santiago, Cynthia Campos Beaver, Erin N Kobetz-Kerman, Natasha Schaefer Solle","doi":"10.1097/JOM.0000000000003477","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Evaluate the association between serum polybrominated diphenyl ether (PBDE) levels and thyroid anatomy and function in firefighters.</p><p><strong>Methods: </strong>259 firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.</p><p><strong>Results: </strong>A positive relationship between PBDE-47 and triiodothyronine (p = 0.02) while an inverse relationship with free thyroxine (p = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size (p = 0.03) and nodule aggressiveness (p = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians (p = 0.01).</p><p><strong>Conclusions: </strong>PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.</p>","PeriodicalId":94100,"journal":{"name":"Journal of occupational and environmental medicine","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Polybrominated diphenyl ethers (PBDEs), Occupational Exposures and Thyroid Function among U.S. and Canadian Firefighters: A Cross-sectional Study.\",\"authors\":\"Bonnie E Gould Rothberg, Alberto J Caban-Martinez, Dana Boyd Barr, Mark A Jara, Valentina Rodriguez, Paola Louzado Feliciano, Katerina M Santiago, Cynthia Campos Beaver, Erin N Kobetz-Kerman, Natasha Schaefer Solle\",\"doi\":\"10.1097/JOM.0000000000003477\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Evaluate the association between serum polybrominated diphenyl ether (PBDE) levels and thyroid anatomy and function in firefighters.</p><p><strong>Methods: </strong>259 firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.</p><p><strong>Results: </strong>A positive relationship between PBDE-47 and triiodothyronine (p = 0.02) while an inverse relationship with free thyroxine (p = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size (p = 0.03) and nodule aggressiveness (p = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians (p = 0.01).</p><p><strong>Conclusions: </strong>PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.</p>\",\"PeriodicalId\":94100,\"journal\":{\"name\":\"Journal of occupational and environmental medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of occupational and environmental medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/JOM.0000000000003477\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of occupational and environmental medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JOM.0000000000003477","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Polybrominated diphenyl ethers (PBDEs), Occupational Exposures and Thyroid Function among U.S. and Canadian Firefighters: A Cross-sectional Study.
Objective: Evaluate the association between serum polybrominated diphenyl ether (PBDE) levels and thyroid anatomy and function in firefighters.
Methods: 259 firefighters provided a blood sample and underwent thyroid ultrasound. Blood serum levels were tested for thyroid function tests and PBDEs -47, -85, -99, -100, -153, and -154 (ng/g lipid weight). Ultrasonography documented structural characteristics. Bivariate associations between PBDE concentrations and demographic/occupational characteristics, thyroid function, and thyroid anatomic measures were determined using multivariable linear regression.
Results: A positive relationship between PBDE-47 and triiodothyronine (p = 0.02) while an inverse relationship with free thyroxine (p = 0.03) was observed. PBDE-47 was inversely associated with thyroid nodule size (p = 0.03) and nodule aggressiveness (p = 0.02). PBDE-47 was highest in western United States firefighters and lowest among sampled Canadians (p = 0.01).
Conclusions: PBDE-47 may contribute to thyroid dysregulation in firefighters. PBDE-47 levels differ across North America.
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