Lorraine E Levitt Katz, Laure K El Ghormli, Kristen J Nadeau, Amy Shah, Janine Higgins, Katherine Kutney, Rose Gubitosi-Klug, Brian Burke, Babak Mokhlesi
{"title":"阻塞性睡眠呼吸暂停、血糖控制和年轻2型糖尿病患者心血管风险：来自TODAY研究的结果","authors":"Lorraine E Levitt Katz, Laure K El Ghormli, Kristen J Nadeau, Amy Shah, Janine Higgins, Katherine Kutney, Rose Gubitosi-Klug, Brian Burke, Babak Mokhlesi","doi":"10.5664/jcsm.11784","DOIUrl":null,"url":null,"abstract":"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.</p><p><strong>Methods: </strong>OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY Study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean: age 23.5 years, diabetes duration 10 years, BMI 35.3 kg/m<sup>2</sup>). HbA1c, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.</p><p><strong>Results: </strong>The prevalence of OSA in TODAY was 38.6%. OSA was not associated with HbA1c, loss of metabolic control, or diabetes-related complications in this cohort.</p><p><strong>Conclusions: </strong>Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Name: TODAY Study; Identifier: NCT00081328.</p>","PeriodicalId":50233,"journal":{"name":"Journal of Clinical Sleep Medicine","volume":" ","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study.\",\"authors\":\"Lorraine E Levitt Katz, Laure K El Ghormli, Kristen J Nadeau, Amy Shah, Janine Higgins, Katherine Kutney, Rose Gubitosi-Klug, Brian Burke, Babak Mokhlesi\",\"doi\":\"10.5664/jcsm.11784\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Study objectives: </strong>Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.</p><p><strong>Methods: </strong>OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY Study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean: age 23.5 years, diabetes duration 10 years, BMI 35.3 kg/m<sup>2</sup>). HbA1c, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.</p><p><strong>Results: </strong>The prevalence of OSA in TODAY was 38.6%. OSA was not associated with HbA1c, loss of metabolic control, or diabetes-related complications in this cohort.</p><p><strong>Conclusions: </strong>Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.</p><p><strong>Clinical trial registration: </strong>Registry: ClinicalTrials.gov; Name: TODAY Study; Identifier: NCT00081328.</p>\",\"PeriodicalId\":50233,\"journal\":{\"name\":\"Journal of Clinical Sleep Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Sleep Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5664/jcsm.11784\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Sleep Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5664/jcsm.11784","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Obstructive sleep apnea, glycemic control, and cardiovascular risk in young adults with youth-onset type 2 diabetes: results from the TODAY study.
Study objectives: Obstructive sleep apnea (OSA) is a common comorbidity in type 2 diabetes and has been associated with poor glycemic control, but few data exist in youth-onset type 2 diabetes. We evaluated the prevalence of OSA and its associations with metabolic control and cardiovascular risk in young adults with pediatric type 2 diabetes.
Methods: OSA presence and severity was assessed by polysomnography in 114 participants in the TODAY Study (Treatment Options for type 2 Diabetes in Adolescents and Youth) (mean: age 23.5 years, diabetes duration 10 years, BMI 35.3 kg/m2). HbA1c, β-cell function, and diabetes-related complications were collected in the TODAY cohort. Adjusted regression models evaluated relationships between OSA and outcomes.
Results: The prevalence of OSA in TODAY was 38.6%. OSA was not associated with HbA1c, loss of metabolic control, or diabetes-related complications in this cohort.
Conclusions: Despite nearly 10 years of poorly controlled diabetes, young adults with youth-onset type 2 diabetes had a moderate prevalence of OSA. Severity of OSA was not associated with loss of glycemic control or diabetes-related complications in the TODAY cohort. The prevalence of OSA was lower than that reported in adults with prediabetes/early type 2 diabetes.
期刊介绍：
Journal of Clinical Sleep Medicine focuses on clinical sleep medicine. Its emphasis is publication of papers with direct applicability and/or relevance to the clinical practice of sleep medicine. This includes clinical trials, clinical reviews, clinical commentary and debate, medical economic/practice perspectives, case series and novel/interesting case reports. In addition, the journal will publish proceedings from conferences, workshops and symposia sponsored by the American Academy of Sleep Medicine or other organizations related to improving the practice of sleep medicine.
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