典型肾血管平滑肌脂肪瘤的假乳头状和微乳头状改变:60例多机构系列分析。

IF 3.4 3区 医学 Q1 PATHOLOGY
Elie Tannous, Deniz Baycelebi, Ankur R Sangoi, Richard R Pacheco, Mohammed A Alghamdi, Andrea R Lightle, Khaleel Al-Obaidy, Sean R Williamson, Zeliha Cetin, Dimitrios Korentzelos, Mahmut Akgul
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引用次数: 0

摘要

典型肾血管平滑肌脂肪瘤(AML)的假乳头状和微乳头状样改变是未被重视的形态学模式,在某些情况下可能导致与肾细胞癌或尿路上皮癌的诊断混淆。为了进一步评估这些形态学的发生率,泌尿生殖系统病理学家回顾性分析了60例典型AML患者的多机构队列。记录临床病理特征包括肿瘤特征、脂肪评估和假乳头状/微乳头状样改变的程度。采用卡方检验确定与肿瘤亚型的关系。大多数病例为单侧(56/60;93%)和独居(55/60;92%),中位肿瘤大小为3.1 cm(范围:0.25 - 19.0 cm)。假乳头状/微乳头状改变在19/60例(32%)中被发现,在脂肪贫乏的AML中更频繁发生(17/30;57%)与非脂肪贫乏AML相比(2/30;7%;p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pseudopapillary and micropapillary-like changes in classical renal angiomyolipoma: a multi-institutional series of 60 cases.

Pseudopapillary- and micropapillary-like changes in classical renal angiomyolipoma (AML) are underappreciated morphologic patterns that in some instances may cause diagnostic confusion with renal cell carcinoma or urothelial carcinoma. To further evaluate the incidence of these morphologies, a multi-institutional cohort of 60 patients with classical AML was retrospectively analyzed by genitourinary pathologists. Clinicopathologic features include tumor characteristics of fat assessment and extent of pseudopapillary/micropapillary-like changes were recorded. Chi-square test was conducted to determine associations with tumor subtype. Most cases were unilateral (56/60; 93%) and solitary (55/60; 92%), with a median tumor size of 3.1 cm (range: 0.25 - 19.0 cm). Pseudopapillary/micropapillary changes were identified in 19/60 cases (32%), significantly occurring more frequently in fat-poor AML (17/30; 57%) compared to non-fat-poor AML (2/30; 7%; p < 0.001). Pseudopapillary/micropapillary growth, mostly in mixed form, within tumors was 20% on average (range: 1 - 60%). No recurrence or tumor-related deaths were observed [44/60 patients; median follow-up = 11 months (range: 1- 96 months)]. Recognizing pseudopapillary/micropapillary features, particularly in fat-poor AML and in a biopsy setting, is critical to avoid misdiagnosis.

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来源期刊
Virchows Archiv
Virchows Archiv 医学-病理学
CiteScore
7.40
自引率
2.90%
发文量
204
审稿时长
4-8 weeks
期刊介绍: Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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