{"title":"阿姆斯特丹胎盘研讨会小组共识声明重新定义:基底慢性绒毛炎。","authors":"T Y Khong, C J Kim, B B Rogers","doi":"10.1007/s00428-025-04152-z","DOIUrl":null,"url":null,"abstract":"<p><p>Villitis of unknown etiology (VUE) can be categorized as distal, proximal, or basal, depending on the type of chorionic villi involved. Either terminal or mature intermediate villi are affected in the distal type, while stem villi are affected in the proximal type. The Amsterdam Placental Workshop Group Consensus Statement did not amplify on the definition of basal VUE. We review the literature to explore the entity, focusing on the terminology, inflammatory infiltrate, involved structures, prevalence, and clinical significance. The prevalence of the lesion, variously defined, in placentas with differing indications for pathological examination and which could include cases with concurrent intraparenchymal VUE ranges from 6.6 to 28.3% of VUE; however, the prevalence of VUE confined only to basal and parabasal villi could be as low as 3%. We propose that the villi that are inflamed must be clearly identified as anchoring or anchored villi; that the preferred term is basal chronic villitis; and that it is diagnosed when chorionic inflammation of anchoring villi, or of villi anchored within the basal plate is seen. No studies have looked specifically at the clinical significance of basal villitis; associations with donor oocyte IVF pregnancies, fetal growth restriction, hypertensive disorders of pregnancy, pre-eclampsia, and morbidly adherent placenta have been reported by some but not confirmed by others. VUE should continue to be reported as intraparenchymal, basal, or mixed until such time that the accumulated experience of the clinical correlates suggests there is no merit in doing so.</p>","PeriodicalId":23514,"journal":{"name":"Virchows Archiv","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Amsterdam Placental Workshop Group Consensus Statement definitions revisited: Basal chronic villitis.\",\"authors\":\"T Y Khong, C J Kim, B B Rogers\",\"doi\":\"10.1007/s00428-025-04152-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Villitis of unknown etiology (VUE) can be categorized as distal, proximal, or basal, depending on the type of chorionic villi involved. Either terminal or mature intermediate villi are affected in the distal type, while stem villi are affected in the proximal type. The Amsterdam Placental Workshop Group Consensus Statement did not amplify on the definition of basal VUE. We review the literature to explore the entity, focusing on the terminology, inflammatory infiltrate, involved structures, prevalence, and clinical significance. The prevalence of the lesion, variously defined, in placentas with differing indications for pathological examination and which could include cases with concurrent intraparenchymal VUE ranges from 6.6 to 28.3% of VUE; however, the prevalence of VUE confined only to basal and parabasal villi could be as low as 3%. We propose that the villi that are inflamed must be clearly identified as anchoring or anchored villi; that the preferred term is basal chronic villitis; and that it is diagnosed when chorionic inflammation of anchoring villi, or of villi anchored within the basal plate is seen. No studies have looked specifically at the clinical significance of basal villitis; associations with donor oocyte IVF pregnancies, fetal growth restriction, hypertensive disorders of pregnancy, pre-eclampsia, and morbidly adherent placenta have been reported by some but not confirmed by others. VUE should continue to be reported as intraparenchymal, basal, or mixed until such time that the accumulated experience of the clinical correlates suggests there is no merit in doing so.</p>\",\"PeriodicalId\":23514,\"journal\":{\"name\":\"Virchows Archiv\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Virchows Archiv\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00428-025-04152-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virchows Archiv","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00428-025-04152-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
Villitis of unknown etiology (VUE) can be categorized as distal, proximal, or basal, depending on the type of chorionic villi involved. Either terminal or mature intermediate villi are affected in the distal type, while stem villi are affected in the proximal type. The Amsterdam Placental Workshop Group Consensus Statement did not amplify on the definition of basal VUE. We review the literature to explore the entity, focusing on the terminology, inflammatory infiltrate, involved structures, prevalence, and clinical significance. The prevalence of the lesion, variously defined, in placentas with differing indications for pathological examination and which could include cases with concurrent intraparenchymal VUE ranges from 6.6 to 28.3% of VUE; however, the prevalence of VUE confined only to basal and parabasal villi could be as low as 3%. We propose that the villi that are inflamed must be clearly identified as anchoring or anchored villi; that the preferred term is basal chronic villitis; and that it is diagnosed when chorionic inflammation of anchoring villi, or of villi anchored within the basal plate is seen. No studies have looked specifically at the clinical significance of basal villitis; associations with donor oocyte IVF pregnancies, fetal growth restriction, hypertensive disorders of pregnancy, pre-eclampsia, and morbidly adherent placenta have been reported by some but not confirmed by others. VUE should continue to be reported as intraparenchymal, basal, or mixed until such time that the accumulated experience of the clinical correlates suggests there is no merit in doing so.
期刊介绍:
Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.