{"title":"老年男性血清睾酮和硫酸脱氢表雄酮水平与听力损失：日立健康研究II。","authors":"Aoi Ito, Shohei Yamamoto, Yosuke Inoue, Ami Fukunaga, Maki Konishi, Katsuyuki Ohara, Shuichiro Yamamoto, Tohru Nakagawa, Tetsuya Mizoue","doi":"10.1097/MAO.0000000000004577","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of serum testosterone and dehydroepiandrosterone sulfate levels with hearing loss in older males.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>A health care center.</p><p><strong>Patients: </strong>This study included 1,421 males aged 60 to 69 yrs who participated in the baseline survey of the Hitachi Health Study II.</p><p><strong>Exposures: </strong>Serum testosterone and DHEAS levels were measured using chemiluminescence and chemiluminescent enzyme immunoassays, respectively.</p><p><strong>Main outcome measures: </strong>Pure-tone audiometric testing was performed to identify hearing loss at 1 and 4 kHz.</p><p><strong>Results: </strong>Higher serum testosterone levels were associated with lower odds of hearing loss at 4 kHz. The OR (95% CI) of hearing loss was 0.71 (0.50, 0.999) for the highest compared with that for the lowest quartile of serum testosterone. A dose-response association was also found between serum testosterone levels and hearing loss at 4 kHz (P for linearity = 0.01). No association was found between serum testosterone levels and hearing loss at 1 kHz (OR for the highest vs lowest quartiles of serum testosterone = 1.06). Serum dehydroepiandrosterone sulfate levels were not associated with hearing loss: the ORs (95% CI) for the highest compared with that for the lowest quartile were 1.01 (0.64, 1.61) and 0.81 (0.58, 1.14) for 1 and 4 kHz, respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that older males with higher serum testosterone levels were less likely to have high-frequency hearing loss.</p>","PeriodicalId":19732,"journal":{"name":"Otology & Neurotology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum Testosterone and Dehydroepiandrosterone Sulfate Levels and Hearing Loss in Older Males: The Hitachi Health Study II.\",\"authors\":\"Aoi Ito, Shohei Yamamoto, Yosuke Inoue, Ami Fukunaga, Maki Konishi, Katsuyuki Ohara, Shuichiro Yamamoto, Tohru Nakagawa, Tetsuya Mizoue\",\"doi\":\"10.1097/MAO.0000000000004577\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to examine the association of serum testosterone and dehydroepiandrosterone sulfate levels with hearing loss in older males.</p><p><strong>Study design: </strong>Cross-sectional study.</p><p><strong>Setting: </strong>A health care center.</p><p><strong>Patients: </strong>This study included 1,421 males aged 60 to 69 yrs who participated in the baseline survey of the Hitachi Health Study II.</p><p><strong>Exposures: </strong>Serum testosterone and DHEAS levels were measured using chemiluminescence and chemiluminescent enzyme immunoassays, respectively.</p><p><strong>Main outcome measures: </strong>Pure-tone audiometric testing was performed to identify hearing loss at 1 and 4 kHz.</p><p><strong>Results: </strong>Higher serum testosterone levels were associated with lower odds of hearing loss at 4 kHz. The OR (95% CI) of hearing loss was 0.71 (0.50, 0.999) for the highest compared with that for the lowest quartile of serum testosterone. A dose-response association was also found between serum testosterone levels and hearing loss at 4 kHz (P for linearity = 0.01). No association was found between serum testosterone levels and hearing loss at 1 kHz (OR for the highest vs lowest quartiles of serum testosterone = 1.06). Serum dehydroepiandrosterone sulfate levels were not associated with hearing loss: the ORs (95% CI) for the highest compared with that for the lowest quartile were 1.01 (0.64, 1.61) and 0.81 (0.58, 1.14) for 1 and 4 kHz, respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that older males with higher serum testosterone levels were less likely to have high-frequency hearing loss.</p>\",\"PeriodicalId\":19732,\"journal\":{\"name\":\"Otology & Neurotology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Otology & Neurotology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/MAO.0000000000004577\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Otology & Neurotology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MAO.0000000000004577","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Serum Testosterone and Dehydroepiandrosterone Sulfate Levels and Hearing Loss in Older Males: The Hitachi Health Study II.
Objective: This study aimed to examine the association of serum testosterone and dehydroepiandrosterone sulfate levels with hearing loss in older males.
Study design: Cross-sectional study.
Setting: A health care center.
Patients: This study included 1,421 males aged 60 to 69 yrs who participated in the baseline survey of the Hitachi Health Study II.
Exposures: Serum testosterone and DHEAS levels were measured using chemiluminescence and chemiluminescent enzyme immunoassays, respectively.
Main outcome measures: Pure-tone audiometric testing was performed to identify hearing loss at 1 and 4 kHz.
Results: Higher serum testosterone levels were associated with lower odds of hearing loss at 4 kHz. The OR (95% CI) of hearing loss was 0.71 (0.50, 0.999) for the highest compared with that for the lowest quartile of serum testosterone. A dose-response association was also found between serum testosterone levels and hearing loss at 4 kHz (P for linearity = 0.01). No association was found between serum testosterone levels and hearing loss at 1 kHz (OR for the highest vs lowest quartiles of serum testosterone = 1.06). Serum dehydroepiandrosterone sulfate levels were not associated with hearing loss: the ORs (95% CI) for the highest compared with that for the lowest quartile were 1.01 (0.64, 1.61) and 0.81 (0.58, 1.14) for 1 and 4 kHz, respectively.
Conclusion: Our findings suggest that older males with higher serum testosterone levels were less likely to have high-frequency hearing loss.
期刊介绍：
Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.
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