预防带状疱疹和呼吸道合胞病毒感染的as01佐剂疫苗可降低痴呆风险。

IF 6.9 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2025-06-25 DOI:10.1038/s41541-025-01172-3

Maxime Taquet, John A Todd, Paul J Harrison

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引用次数: 0

摘要

as01佐剂带状疱疹疫苗与较低的痴呆风险相关，但其潜在机制尚不清楚。在436,788名个体的倾向评分匹配队列研究中，as01辅助带状疱疹和呼吸道合胞病毒（RSV）疫苗（单独或联合）与降低18个月痴呆风险相关。两种AS01佐剂疫苗之间没有观察到差异，这表明AS01佐剂本身在降低痴呆风险方面起直接作用。

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Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections.

AS01-adjuvanted shingles (herpes zoster) vaccination is associated with a lower risk of dementia, but the underlying mechanisms are unclear. In propensity-score matched cohort studies with 436,788 individuals, both the AS01-adjuvanted shingles and respiratory syncytial virus (RSV) vaccines, individually or combined, were associated with reduced 18-month risk of dementia. No difference was observed between the two AS01-adjuvanted vaccines, suggesting that the AS01 adjuvant itself plays a direct role in lowering dementia risk.

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.