{"title":"胰腺癌淋巴结位置指标对预后的影响及对最佳区域淋巴结位置的重新考虑。","authors":"Suguru Yamada, Tsutomu Fujii, Kenji Oshima, Kosuke Nomoto, Yukiko Oshima, Masamichi Hayashi, Akimasa Nakao","doi":"10.1002/jhbp.12179","DOIUrl":null,"url":null,"abstract":"<p><strong>Purposes: </strong>Regional lymphadenectomy is standard in pancreatic cancer. The aim was to explore clinical impact for the prognostic index of nodal stations and optimal extent of lymphadenectomy in pancreatic cancer.</p><p><strong>Methods: </strong>A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.</p><p><strong>Results: </strong>In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.</p><p><strong>Conclusion: </strong>Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer.\",\"authors\":\"Suguru Yamada, Tsutomu Fujii, Kenji Oshima, Kosuke Nomoto, Yukiko Oshima, Masamichi Hayashi, Akimasa Nakao\",\"doi\":\"10.1002/jhbp.12179\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purposes: </strong>Regional lymphadenectomy is standard in pancreatic cancer. The aim was to explore clinical impact for the prognostic index of nodal stations and optimal extent of lymphadenectomy in pancreatic cancer.</p><p><strong>Methods: </strong>A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.</p><p><strong>Results: </strong>In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.</p><p><strong>Conclusion: </strong>Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.</p>\",\"PeriodicalId\":16056,\"journal\":{\"name\":\"Journal of Hepato‐Biliary‐Pancreatic Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepato‐Biliary‐Pancreatic Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jhbp.12179\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepato‐Biliary‐Pancreatic Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jhbp.12179","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Clinical Impact for Prognostic Index of Nodal Stations and Reconsideration of Optimal Regional Lymph Node Station in Pancreatic Cancer.
Purposes: Regional lymphadenectomy is standard in pancreatic cancer. The aim was to explore clinical impact for the prognostic index of nodal stations and optimal extent of lymphadenectomy in pancreatic cancer.
Methods: A total of 507 consecutive pancreatic cancer patients who underwent a surgery-first approach and unified systemic lymphadenectomy were enrolled. The prognostic index of nodal stations was calculated by tumor location and relevant lymph node (LN) station, and clinicopathological factors and survival outcomes were analyzed.
Results: In the pancreatic head, LN13 dissection showed the highest prognostic index, with extremely low indices for LN6 and LN12 dissection. In the pancreatic body, LN11 dissection showed the highest index; LN9 and LN10 dissection both had indices of zero. In the pancreatic tail, LN11 dissection showed the highest index, and that for LN8 dissection was zero. Subgroup analyses of the prognostic index according to resectability status, peritoneal cytology, pathological stage, and the administration of postoperative adjuvant therapy were performed, and the overall pattern remained unchanged.
Conclusion: Regional lymphadenectomy is basically indispensable, considering LN metastasis, and the prognostic index of nodal stations showed the clinical impact on survival analysis. Also, it might be possible to omit some LN dissection based on the tumor location.
期刊介绍：
The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.
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