[68Ga]Ga-PSMA-11与[18F]F-PSMA-1007 PET/CT对前列腺根治术和淋巴结清扫患者淋巴结分期的诊断准确性评估:一项单一的机构分析。

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Paola Arena, Vittorio Fasulo, Fabrizia Gelardi, Nicola Frego, Jelena Jandric, Davide Maffei, Pier Paolo Avolio, Marco Paciotti, Giuseppe Chiarelli, Fabio De Carne, Filippo Dagnino, Andrea Piccolini, Egesta Lopci, Rodolfo Hurle, Alberto Saita, Arturo Chiti, Massimo Lazzeri, Laura Evangelista, Nicolò Maria Buffi, Paolo Casale, Giovanni Lughezzani
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引用次数: 0

摘要

背景/目的:本研究评估并比较了[68Ga]Ga-PSMA-11和[18F]F-PSMA-1007对机器人辅助根治性前列腺切除术(RARP)和淋巴结切除术(LND)前列腺癌(PCa)患者淋巴结分期的诊断准确性。方法:我们回顾性分析了2020年10月至2023年1月在我院转诊的患者的前瞻性数据。我们纳入了所有接受了[68Ga]Ga-PSMA-11或[18F]F-PSMA-1007 PET/CT进行初步分期并随后出现RARP合并LND的患者。报告了淋巴结(LNs)的最大标准摄取值(SUVmax)和SUV节点与背景比。SUV节点背景比的两个不同临界值(即≥2 vs.结果):共纳入156例患者(中位年龄:67岁)。其中83例行[68Ga]Ga-PSMA-11 PET/CT, 73例行[18F]F-PSMA-1007 PET/CT。可疑淋巴结21例(13.5%)。病理淋巴结受累(pN1) 25例(16%)。在21例PSMA PET/CT可疑病理淋巴结患者中,9例(42.9%)最终病理报告为淋巴结阳性。在SUV节点背景比临界值≥2时,[68Ga]Ga-PSMA-11的敏感性为37.5%,特异性为98.5%,而[18F]F-PSMA-1007的敏感性为33.3%,特异性为100%。使用≥15.5的临界值,[68Ga]Ga-PSMA-11的SE和SP分别为31.3%和100%,[18F]F-PSMA-1007的SE和SP分别为11.1%和100%。结论:无论采用何种SUV比例,[18F]F-PSMA-1007 PET/CT显示,与[68Ga]Ga-PSMA-11 PET/CT相比,淋巴结分期的SE略低,SP略高,即使没有统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Evaluation of the Diagnostic Accuracy of [68Ga]Ga-PSMA-11 vs. [18F]F-PSMA-1007 PET/CT for Lymph Node Staging in Patient Candidates for Radical Prostatectomy and Lymph Node Dissection: A Single Institutional Analysis.

Background/Objectives: This study evaluates and compares the diagnostic accuracy of [68Ga]Ga-PSMA-11 and [18F]F-PSMA-1007 for lymph node staging in patients with prostate cancer (PCa) scheduled for robot-assisted radical prostatectomy (RARP) and lymphadenectomy (LND). Methods: We retrospectively reviewed prospectively collected data on patients referred to our hospital from October 2020 to January 2023. We included all patients who underwent [68Ga]Ga-PSMA-11 or [18F]F-PSMA-1007 PET/CT for primary staging and subsequently had RARP with concomitant LND. The maximum standard uptake value (SUVmax) for lymph nodes (LNs) and the SUV node-to-background ratio were reported. Two different cut-off values for the SUV node-to-background ratio (i.e., ≥2 vs. <2 and ≥15.5 vs. <15.5) were used to evaluate the diagnostic performance of both tracers. The first cut-off was empirically chosen, while the second was based on Liu's method. Results: A total of 156 patients were included (median age: 67 years). Among them, 83 underwent [68Ga]Ga-PSMA-11 and 73 underwent [18F]F-PSMA-1007 PET/CT. Suspicious lymph nodes were identified in 21 patients (13.5%). Pathological nodal involvement (pN1) was confirmed in 25 cases (16%). Of the 21 patients with suspicious pathological lymph nodes on PSMA PET/CT, 9 (42.9%) had positive nodes on the final pathology report. With an SUV node-to-background ratio cut-off of ≥2, [68Ga]Ga-PSMA-11 showed 37.5% sensitivity (SE) and 98.5% specificity(SP), while [18F]F-PSMA-1007 demonstrated 33.3% SE and 100% SP. Using the ≥15.5 cut-off, SE and SP were 31.3% and 100% for [68Ga]Ga-PSMA-11 and 11.1% and 100% for [18F]F-PSMA-1007, respectively. Conclusions: [18F]F-PSMA-1007 PET/CT showed, even if not statistically significantly, slightly lower SE and higher SP for nodal staging compared to [68Ga]Ga-PSMA-11 PET/CT, irrespective of the SUV ratio used.

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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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